{"id":"W4382198941","doi":"10.1101/2023.06.27.545921","title":"Paridiprubart inhibits TLR4-dependant NF-κB activation by multiple pathogens","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Canada Research Chairs; Sunnybrook Hospital; University of Toronto","funders":"","keywords":"TLR4; Cytokine storm; HMGB1; ARDS; Innate immune system; Immunology; Inflammation; Lipopolysaccharide; Receptor; Immune system; Biology; Context (archaeology); Proinflammatory cytokine; Pattern recognition receptor; Agonist; Pathogen; Toll-like receptor; Medicine; Lung; Coronavirus disease 2019 (COVID-19); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162373,0.0004301487,0.0004133906,0.0003131106,0.0001749185,0.0002258511,0.0004321908,0.0003744333,0.003181686],"category_scores_gemma":[0.0001540089,0.0001896894,0.0002817948,0.0001682936,0.0001940369,0.0001944952,0.000171603,0.0009617968,0.0006987333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919844,"about_ca_system_score_gemma":0.0002174065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003178829,"about_ca_topic_score_gemma":0.0004146147,"domain_scores_codex":[0.9998908,0.00001970227,0.00001077489,0.00001400661,0.00002118767,0.00004353543],"domain_scores_gemma":[0.9999299,0.00001386163,0.00001547789,0.00000916219,0.000008395143,0.0000232506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002163301,0.001143962,0.0001913743,0.0002171532,0.0000422695,0.0001247647,0.00001724788,0.000227762,0.9816387,0.0001289026,0.0006430983,0.01346154],"study_design_scores_gemma":[0.0008529554,0.009756928,0.005312377,0.00002106261,0.00006771552,0.001151534,0.00002922302,0.002396726,0.9737172,0.0001008396,0.006577644,0.00001580138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858598,0.005084821,0.002585775,0.0003280234,0.0001751865,0.000117999,0.0005105104,0.0004736266,0.004864206],"genre_scores_gemma":[0.9943516,0.001461109,0.001190532,0.0001782552,0.00004386094,0.00007112052,0.0006492162,0.0000192801,0.002034905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003181686,"threshold_uncertainty_score":0.01064384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531694298008568,"score_gpt":0.211487014815904,"score_spread":0.1961700718358183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}