{"id":"W4382199204","doi":"10.1093/jnci/djad116","title":"Contralateral breast cancer risk in patients with breast cancer and a germline-<i>BRCA1/2</i> pathogenic variant undergoing radiation","year":2023,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; McGill University","funders":"Centre Léon Bérard; Institut Claudius Regaud; Institut National Du Cancer; Direction Générale de l’offre de Soins; Medizinische Universität Wien; Leids Universitair Medisch Centrum; Ministerio de Ciencia e Innovación; Maastricht Universitair Medisch Centrum; Odense Universitetshospital; Radboud Universitair Medisch Centrum; Fondation de France; Great Ormond Street Hospital for Children; Rijksuniversiteit Groningen; Ministerio de Economía y Competitividad; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Institut Gustave-Roussy; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Instituto de Salud Carlos III; Radboud Universiteit; Newcastle upon Tyne Hospitals NHS Foundation Trust; Universiteit Leiden; Institut Bergonié; Deutsche Krebshilfe; University of Glasgow; Ministero dello Sviluppo Economico; Universiteit van Amsterdam; KWF Kankerbestrijding; Nottingham University Hospitals NHS Trust; Cancer Research UK; University of Southampton; Bundesministerium für Bildung und Forschung; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institute for Health and Care Research; University of Nottingham; Central Manchester University Hospitals NHS Foundation Trust; Universität Wien; National Institute on Handicapped Research; Amsterdam University Medical Centers; Universiteit Maastricht; Fondation ARC pour la Recherche sur le Cancer; Royal Marsden NHS Foundation Trust; Canadian Institutes of Health Research; Fundación Mutua Madrileña","keywords":"Medicine; Breast cancer; Internal medicine; Hazard ratio; Oncology; Proportional hazards model; Confidence interval; Prospective cohort study; Radiation therapy; Cancer; Gastroenterology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002784785,0.0001617113,0.0002711236,0.0003499965,0.0002786883,0.0003910469,0.0002336668,0.0003699719,0.0021512],"category_scores_gemma":[0.001601357,0.0001885282,0.0004233765,0.0005504923,0.0001804108,0.0002329063,0.0002438159,0.0004472913,0.0001958826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011641,"about_ca_system_score_gemma":0.0003203859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003844212,"about_ca_topic_score_gemma":0.003614689,"domain_scores_codex":[0.9998319,0.00003143591,0.00001183406,0.00005256768,0.00003000602,0.00004227204],"domain_scores_gemma":[0.999321,0.0001220972,0.0003416899,0.00004767036,0.00003100668,0.0001366696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001249717,0.00001573813,0.998745,0.000003495826,0.00001537234,0.0001679448,0.00001743435,0.00003696649,0.00009829934,0.00001054241,0.00006480569,0.0006995734],"study_design_scores_gemma":[0.00001935548,0.0001625777,0.9975371,0.000005747238,0.00005260417,0.001522095,0.0000860403,0.0002941485,0.00006071436,0.00005140593,0.0002036138,0.00000446526],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992945,0.0001857786,0.00003939283,0.0000367657,0.000006890963,0.000002785685,0.0001198385,0.000002859717,0.0003110669],"genre_scores_gemma":[0.999662,0.00005852235,0.00003095889,0.00002146412,0.00001077641,0.000002689469,0.0001291493,0.000001163012,0.00008315783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003844212,"threshold_uncertainty_score":0.00764364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009311783956677434,"score_gpt":0.2651961506326801,"score_spread":0.2558843666760027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}