{"id":"W4382343789","doi":"10.1002/adhm.202300793","title":"Moderate‐Affinity Affibodies Modulate the Delivery and Bioactivity of Bone Morphogenetic Protein‐2","year":2023,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; National Institutes of Health; University of Oregon; Congressionally Directed Medical Research Programs; Collins Medical Trust; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Self-healing hydrogels; C2C12; Bone morphogenetic protein 2; Chemistry; Bone morphogenetic protein; Biophysics; Polyethylene glycol; Alkaline phosphatase; Molecular biology; Biochemistry; In vitro; Biology; Polymer chemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002974228,0.0001343568,0.0002106172,0.00004318207,0.0001930644,0.00002195687,0.00007910379,0.00009029351,0.00001373191],"category_scores_gemma":[0.00007294436,0.000106549,0.00004392535,0.00009287659,0.00006041954,0.000007547127,0.0001532256,0.00006688349,0.000007289773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009933525,"about_ca_system_score_gemma":0.00004684125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002025516,"about_ca_topic_score_gemma":0.0001233063,"domain_scores_codex":[0.9989932,0.0001517653,0.0002648151,0.0002734651,0.00009286329,0.0002239503],"domain_scores_gemma":[0.9993349,0.00001993426,0.0001438224,0.0003298677,0.0001175972,0.00005389075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001487657,0.00001717606,0.00001297245,0.00009752445,0.00002216153,0.000001957039,0.00005026206,0.0001118638,0.9974463,0.0004788825,0.00003984633,0.001572283],"study_design_scores_gemma":[0.0002055983,0.0002275779,0.0005759669,0.00003592688,0.000008235966,0.000009304976,0.0001286704,0.0001247526,0.9960992,0.001366518,0.001104642,0.0001135581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973165,0.0008327793,0.0001786852,0.0007693199,0.0002397628,0.0004316132,0.0001899094,0.00002330877,0.00001811626],"genre_scores_gemma":[0.9975525,0.001591703,0.0002866646,0.00009627824,0.00007150837,0.00008629517,0.0001229051,0.00002178412,0.0001703384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458725,"threshold_uncertainty_score":0.4344943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782756688078171,"score_gpt":0.2710003890600363,"score_spread":0.2531728221792546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}