{"id":"W4382343789","doi":"10.1002/adhm.202300793","title":"Moderate‐Affinity Affibodies Modulate the Delivery and Bioactivity of Bone Morphogenetic Protein‐2","year":2023,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; National Institutes of Health; University of Oregon; Congressionally Directed Medical Research Programs; Collins Medical Trust; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Self-healing hydrogels; C2C12; Bone morphogenetic protein 2; Chemistry; Bone morphogenetic protein; Biophysics; Polyethylene glycol; Alkaline phosphatase; Molecular biology; Biochemistry; In vitro; Biology; Polymer chemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052361,0.0004395079,0.000185714,0.000126427,0.0001365992,0.0003621726,0.0002725477,0.0002880915,0.001079703],"category_scores_gemma":[0.0001413383,0.0001805528,0.0001581686,0.0001243936,0.0001849381,0.0002260961,0.0002461343,0.0003680701,0.0003493317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003769628,"about_ca_system_score_gemma":0.0001441694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006533963,"about_ca_topic_score_gemma":0.001236433,"domain_scores_codex":[0.9998637,0.00001249921,0.000009267067,0.00002328497,0.0000403599,0.00005069411],"domain_scores_gemma":[0.9999467,0.00001544972,0.00001508884,0.000002941746,0.000006430157,0.00001336168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003685883,0.00002115666,0.0001011327,0.00001702403,0.000002823097,0.00001168703,0.000005667901,0.0001394745,0.9987856,0.00007376516,0.00003189273,0.0007729185],"study_design_scores_gemma":[0.000009085856,0.00006188366,0.0008711824,0.000001823424,0.000004923002,0.00002624125,0.000007834291,0.00173474,0.9966258,0.00002370085,0.00062848,0.000004428802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949796,0.0007209401,0.002615992,0.0000482939,0.00001529411,0.00001713068,0.00006424296,0.00006051152,0.001478054],"genre_scores_gemma":[0.9967884,0.0004626314,0.001630904,0.00005394846,0.000006299865,0.00002790111,0.0000621033,0.00001320028,0.0009546411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079703,"threshold_uncertainty_score":0.003611982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782756688078171,"score_gpt":0.2710003890600363,"score_spread":0.2531728221792546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}