{"id":"W4382344241","doi":"10.1093/brain/awad218","title":"The risk of secondary progressive multiple sclerosis is geographically determined but modifiable","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; McGill University; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Hôpital Charles-Le Moyne; St. Michael's Hospital; Université de Montréal","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Sanofi Genzyme; Novartis Pharma; Multiple Sclerosis Society; Multiple Sclerosis Australia; Genentech; F. Hoffmann-La Roche; Grifols; Università di Catania; Multiple Sclerosis Society of Canada; Bayer Schering; Mylan; Medical Research Council; Teva Pharmaceutical Industries; Royal Melbourne Hospital Neuroscience Foundation; University of Melbourne; Novartis; Fondazione Italiana Sclerosi Multipla; Celgene; Biogen; Alexion Pharmaceuticals; Dementia Australia; Merck; Sanofi; EMD Serono; Monash University; Roche","keywords":"Multiple sclerosis; Medicine; Proportional hazards model; Cohort; Residence; Physical therapy; Demography; Pediatrics; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001272349,0.0002560548,0.0005763873,0.0006036636,0.000263209,0.0005378974,0.0004176795,0.000423748,0.00223312],"category_scores_gemma":[0.005121053,0.0002939028,0.001138352,0.001127184,0.0004870382,0.0003185652,0.0007856479,0.0004220929,0.0002465587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002794096,"about_ca_system_score_gemma":0.0003333763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003504223,"about_ca_topic_score_gemma":0.002778719,"domain_scores_codex":[0.9984787,0.0007323282,0.0001159607,0.0003281093,0.000190734,0.0001542126],"domain_scores_gemma":[0.9971396,0.0008793173,0.001309442,0.0004100673,0.000118061,0.0001435686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006445051,0.00002014812,0.9906836,0.000090646,0.0006889644,0.0003399473,0.00009276233,0.001255253,0.0003059626,0.0001641893,0.0001711715,0.005542934],"study_design_scores_gemma":[0.00002158098,0.0001580555,0.9973655,0.00001788899,0.0001600272,0.0006638236,0.00006146348,0.0007827433,0.0000727788,0.0003199407,0.0003687566,0.00000736604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946203,0.001826777,0.001247299,0.0001544643,0.000009847698,0.00002136316,0.0009917573,0.00002674511,0.001101462],"genre_scores_gemma":[0.9991554,0.0002522792,0.0001791746,0.00001722797,0.0000100189,0.00000832059,0.0002672967,0.000003005046,0.0001073444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003504223,"threshold_uncertainty_score":0.007470548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05306188040560815,"score_gpt":0.3000342832834825,"score_spread":0.2469724028778743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}