{"id":"W4382344241","doi":"10.1093/brain/awad218","title":"The risk of secondary progressive multiple sclerosis is geographically determined but modifiable","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; McGill University; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Hôpital Charles-Le Moyne; St. Michael's Hospital; Université de Montréal","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Sanofi Genzyme; Novartis Pharma; Multiple Sclerosis Society; Multiple Sclerosis Australia; Genentech; F. Hoffmann-La Roche; Grifols; Università di Catania; Multiple Sclerosis Society of Canada; Bayer Schering; Mylan; Medical Research Council; Teva Pharmaceutical Industries; Royal Melbourne Hospital Neuroscience Foundation; University of Melbourne; Novartis; Fondazione Italiana Sclerosi Multipla; Celgene; Biogen; Alexion Pharmaceuticals; Dementia Australia; Merck; Sanofi; EMD Serono; Monash University; Roche","keywords":"Multiple sclerosis; Medicine; Proportional hazards model; Cohort; Residence; Physical therapy; Demography; Pediatrics; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006683,0.0001913901,0.0003821121,0.0002072428,0.0004436155,0.000040898,0.0002754232,0.0001004137,0.0001253778],"category_scores_gemma":[0.004675312,0.0001221395,0.0002575934,0.0008273345,0.0005775623,0.00006808873,0.0003099426,0.0003640828,0.00008852336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002936396,"about_ca_system_score_gemma":0.0001310606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003759062,"about_ca_topic_score_gemma":0.00006602395,"domain_scores_codex":[0.9977851,0.00017617,0.0004016386,0.0003634984,0.0006658722,0.0006077187],"domain_scores_gemma":[0.9966058,0.002108962,0.000175906,0.0006265013,0.0002977282,0.0001851724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001232291,0.0003763094,0.3139137,0.000505998,0.001478881,0.00007543651,0.001965211,0.0000445385,0.2065893,0.00005325594,0.1712382,0.3025268],"study_design_scores_gemma":[0.003680501,0.0004169268,0.9465309,0.0002796841,0.00007339464,0.000005196484,0.0008279426,0.01382503,0.02334624,0.0001663277,0.01064985,0.0001979845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903931,0.0007796364,0.00002031917,0.006385926,0.00008842895,0.001088309,0.0002745077,0.0001672551,0.0008025054],"genre_scores_gemma":[0.9941204,0.001925029,0.0006262455,0.0003349532,0.0001163753,0.000337778,0.00002809472,0.00003906612,0.00247206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6326172,"threshold_uncertainty_score":0.5597123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05306188040560815,"score_gpt":0.3000342832834825,"score_spread":0.2469724028778743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}