{"id":"W4382363169","doi":"10.1056/nejmoa2207940","title":"Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":317,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Eli Lilly and Company","keywords":"Ulcerative colitis; Maintenance therapy; Induction therapy; Medicine; Colitis; Internal medicine; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001624198,0.0004528724,0.001469737,0.000544966,0.0002600255,0.0004145901,0.0006034997,0.0006801154,0.002674972],"category_scores_gemma":[0.001260641,0.0002185811,0.000562701,0.0003662551,0.000461094,0.0005210695,0.0003422645,0.00150531,0.0004851442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003697712,"about_ca_system_score_gemma":0.0004960409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001450006,"about_ca_topic_score_gemma":0.0003270785,"domain_scores_codex":[0.9994447,0.0002344755,0.00006553729,0.00008069009,0.00009825149,0.00007632739],"domain_scores_gemma":[0.9991956,0.0002174028,0.0002155191,0.00008536227,0.00003546666,0.0002506253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5102494,0.01519688,0.007895957,0.001828745,0.0008354492,0.0002129171,0.0002029212,0.0005385435,0.02634184,0.000343145,0.001612251,0.4347419],"study_design_scores_gemma":[0.5614377,0.380384,0.03967648,0.000379998,0.001188323,0.0008199937,0.00004776142,0.001108119,0.007489113,0.0002883678,0.007129511,0.00005069762],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692487,0.0255027,0.0009739268,0.0005337241,0.0002148158,0.001313078,0.0002195626,0.0001274912,0.001866007],"genre_scores_gemma":[0.9890886,0.005609388,0.00182454,0.0004764938,0.0003136426,0.001493414,0.000356338,0.00001290939,0.0008246539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002674972,"threshold_uncertainty_score":0.008948684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448433400765308,"score_gpt":0.2820073018861158,"score_spread":0.2675229678784627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}