{"id":"W4382363169","doi":"10.1056/nejmoa2207940","title":"Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":317,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Eli Lilly and Company","keywords":"Ulcerative colitis; Maintenance therapy; Induction therapy; Medicine; Colitis; Internal medicine; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004223063,0.00007486091,0.0001194979,0.00005550742,0.0000426199,0.000005998376,0.00005555159,0.0000488073,0.0000213559],"category_scores_gemma":[0.0003143828,0.00005171984,0.00003314362,0.00004727765,0.00006799884,0.000004874951,0.00001015176,0.00006615172,0.000001558803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000881173,"about_ca_system_score_gemma":0.000115693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000768039,"about_ca_topic_score_gemma":0.00002075512,"domain_scores_codex":[0.9994594,0.00004758599,0.0001790378,0.00009065582,0.0001092461,0.0001140936],"domain_scores_gemma":[0.9994938,0.00002702783,0.0001196796,0.00007033995,0.0001635618,0.0001255244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03974668,0.00006076678,0.003331851,0.00008233038,0.0004329267,0.0006390074,0.002632053,0.00007143341,0.1497966,0.00139808,0.2745172,0.5272911],"study_design_scores_gemma":[0.08427075,0.004602172,0.391887,0.0001976342,0.00006634821,0.001082811,0.0008602951,0.00005991088,0.01112653,0.006124248,0.4994921,0.0002301437],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952903,0.000368351,0.0003809291,0.003178633,0.0003752423,0.0001386985,0.000004910889,0.000004254858,0.0002586261],"genre_scores_gemma":[0.9931296,0.001638905,0.0001313641,0.0005262827,0.003327558,0.000004507453,0.00001880407,0.0000116837,0.001211314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5270609,"threshold_uncertainty_score":0.2109074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448433400765308,"score_gpt":0.2820073018861158,"score_spread":0.2675229678784627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}