{"id":"W4382363527","doi":"10.1158/1078-0432.ccr-22-3146","title":"Early Clearance of Plasma <i>Epidermal Growth Factor Receptor</i> Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Osimertinib; Lung cancer; Erlotinib; Medicine; T790M; Gefitinib; Internal medicine; Oncology; Epidermal growth factor receptor; Tyrosine-kinase inhibitor; Confidence interval; Genotyping; Cancer; Genotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001793457,0.0003535975,0.0005062454,0.0002720373,0.0002197991,0.0006519995,0.0003329758,0.0003735787,0.001040346],"category_scores_gemma":[0.001661302,0.0001598901,0.001127075,0.0002921099,0.0003017112,0.0003319992,0.000345908,0.0007087154,0.000190637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004847569,"about_ca_system_score_gemma":0.0004064038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006399793,"about_ca_topic_score_gemma":0.0009564465,"domain_scores_codex":[0.9993978,0.0002320693,0.00004164099,0.0001497849,0.0001100569,0.00006865006],"domain_scores_gemma":[0.9982882,0.0005546769,0.0005762337,0.0001365261,0.0001107777,0.0003334931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03881172,0.0004780638,0.9414588,0.0001041709,0.001250167,0.0001641679,0.0001128889,0.0004985477,0.005319156,0.00005636673,0.0003252581,0.01142074],"study_design_scores_gemma":[0.001117159,0.00890351,0.9832312,0.00002285024,0.001085855,0.0008881257,0.00009633128,0.001780741,0.002011336,0.0001197666,0.0007249884,0.00001819365],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991704,0.0002995869,0.00008269576,0.00001881856,0.000003478408,0.00001970724,0.0002040645,0.000003481575,0.0001976735],"genre_scores_gemma":[0.9995406,0.0000360646,0.00005876286,0.00001564017,0.000007883264,0.00001311169,0.0002498171,0.000001253304,0.00007695864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793457,"threshold_uncertainty_score":0.009484828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1159411974898816,"score_gpt":0.4822468623266429,"score_spread":0.3663056648367613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}