{"id":"W4382393384","doi":"10.1016/j.bpsgos.2023.04.007","title":"Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions","year":2023,"lang":"en","type":"article","venue":"Biological Psychiatry Global Open Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; University of Ottawa; Université Laval","funders":"Institute of Neurosciences, Mental Health and Addiction; Fonds de Recherche du Québec - Santé; Sentinelle Nord, Université Laval; Fonds de recherche du Québec; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Jejunum; Tight junction; Gut–brain axis; Barrier function; Chronic stress; Major depressive disorder; Blood–brain barrier; Gut flora; Social defeat; Lipopolysaccharide; Biology; Immunology; Medicine; Endocrinology; Cell biology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192495,0.000297679,0.0002653444,0.0002772924,0.0001642157,0.0002893804,0.0001099651,0.0002940163,0.001379773],"category_scores_gemma":[0.000181918,0.0001386717,0.0002884727,0.0001526879,0.0002146115,0.0001667935,0.0002477402,0.0004507833,0.0001470004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622825,"about_ca_system_score_gemma":0.0001545652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005326893,"about_ca_topic_score_gemma":0.001078976,"domain_scores_codex":[0.99986,0.00002155657,0.000009590964,0.00004722337,0.0000279762,0.00003365591],"domain_scores_gemma":[0.9998234,0.00001468895,0.00008016057,0.00001374467,0.00002172579,0.00004632667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001210852,0.00009581632,0.02563145,0.0001657864,0.00008912336,0.0001580642,0.0001074265,0.00004920808,0.9627717,0.00006655079,0.0001555295,0.009498526],"study_design_scores_gemma":[0.00003166144,0.001890278,0.8920602,0.00006556338,0.0001540304,0.0006583886,0.0003813096,0.000523774,0.1025168,0.0001908194,0.001503813,0.0000232724],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950912,0.002787785,0.0009369949,0.0001586505,0.00003053532,0.00001456615,0.0005699439,0.00002734867,0.0003830932],"genre_scores_gemma":[0.9963405,0.001691354,0.0006896326,0.0001367732,0.00002006984,0.00003428145,0.0003801549,0.00001212707,0.0006950596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379773,"threshold_uncertainty_score":0.004615843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864819334015617,"score_gpt":0.303958022641103,"score_spread":0.2853098293009468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}