{"id":"W4382394400","doi":"10.1038/s41586-023-06250-x","title":"Locus for severity implicates CNS resilience in progression of multiple sclerosis","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":227,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute of Nursing Research; NIHR Cambridge Biomedical Research Centre; Multiple Sclerosis Society of Western Australia; EMD Serono; Kaiser Permanente; National Multiple Sclerosis Society; Red Española de Esclerosis Múltiple; Mitsubishi Tanabe Pharma Corporation; Sanofi; TG Therapeutics; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Vetenskapsrådet; Menzies Institute for Medical Research; Knut och Alice Wallenbergs Stiftelse; Novartis Institutes for BioMedical Research; Sanofi Genzyme; KU Leuven; Fonds Wetenschappelijk Onderzoek; Sun Yat-sen University; Bundesministerium für Bildung und Forschung; Bristol-Myers Squibb Foundation; Deutsche Forschungsgemeinschaft; Multiple Sclerosis Society; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; Genentech; National Institute for Health and Care Research; Vlaamse regering; International Progressive MS Alliance; National Institutes of Health; Regeneron Pharmaceuticals; Max-Planck-Gesellschaft; Teva Pharmaceutical Industries; Helsingin Yliopisto; Bristol-Myers Squibb; University of Tasmania; Yale University; Alexion Pharmaceuticals; Biogen; Università degli Studi del Piemonte Orientale; Celgene; Idorsia Pharmaceuticals; Instituto de Salud Carlos III; Disarm Therapeutics; Eli Lilly and Company; Race to Erase MS; Multiple Sclerosis Society of Canada; Amgen; University of California, San Francisco; Ministero della Salute","keywords":"Multiple sclerosis; Locus (genetics); Neuroscience; Psychology; Resilience (materials science); Biology; Genetics; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001739172,0.0005182771,0.0003837217,0.001509701,0.0008044377,0.0009068123,0.000462647,0.0005354272,0.005027207],"category_scores_gemma":[0.009502986,0.0001612682,0.0007251163,0.001029171,0.0008252399,0.0006890285,0.001274133,0.0009870803,0.0001863988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427527,"about_ca_system_score_gemma":0.0007159826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004145944,"about_ca_topic_score_gemma":0.004476263,"domain_scores_codex":[0.9988878,0.0005185829,0.00007642539,0.000173211,0.0001830275,0.0001609102],"domain_scores_gemma":[0.9936668,0.001490853,0.002642052,0.0008299047,0.0004332513,0.0009370396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008364353,0.0001398052,0.9855736,0.00002752481,0.0003182414,0.0002876327,0.0006879745,0.0001626858,0.003393187,0.0009150892,0.0001554278,0.007502296],"study_design_scores_gemma":[0.00000796128,0.000178982,0.9978188,0.00001000436,0.00006843847,0.0002251746,0.0002668224,0.0001238939,0.0003095896,0.0008354163,0.0001480781,0.000006829689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997344,0.0001650937,0.0002755709,0.0003032217,0.00001235568,0.000005773986,0.0001369976,0.000008640643,0.001748418],"genre_scores_gemma":[0.9995858,0.00002567574,0.0001190597,0.00001614759,0.000008791048,0.000001896858,0.00004422219,0.000002549023,0.0001959521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005027207,"threshold_uncertainty_score":0.01681769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06054588484409179,"score_gpt":0.3783048962027753,"score_spread":0.3177590113586835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}