{"id":"W4382394400","doi":"10.1038/s41586-023-06250-x","title":"Locus for severity implicates CNS resilience in progression of multiple sclerosis","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":227,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute of Nursing Research; NIHR Cambridge Biomedical Research Centre; Multiple Sclerosis Society of Western Australia; EMD Serono; Kaiser Permanente; National Multiple Sclerosis Society; Red Española de Esclerosis Múltiple; Mitsubishi Tanabe Pharma Corporation; Sanofi; TG Therapeutics; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Vetenskapsrådet; Menzies Institute for Medical Research; Knut och Alice Wallenbergs Stiftelse; Novartis Institutes for BioMedical Research; Sanofi Genzyme; KU Leuven; Fonds Wetenschappelijk Onderzoek; Sun Yat-sen University; Bundesministerium für Bildung und Forschung; Bristol-Myers Squibb Foundation; Deutsche Forschungsgemeinschaft; Multiple Sclerosis Society; Erasmus Universitair Medisch Centrum Rotterdam; European Commission; Genentech; National Institute for Health and Care Research; Vlaamse regering; International Progressive MS Alliance; National Institutes of Health; Regeneron Pharmaceuticals; Max-Planck-Gesellschaft; Teva Pharmaceutical Industries; Helsingin Yliopisto; Bristol-Myers Squibb; University of Tasmania; Yale University; Alexion Pharmaceuticals; Biogen; Università degli Studi del Piemonte Orientale; Celgene; Idorsia Pharmaceuticals; Instituto de Salud Carlos III; Disarm Therapeutics; Eli Lilly and Company; Race to Erase MS; Multiple Sclerosis Society of Canada; Amgen; University of California, San Francisco; Ministero della Salute","keywords":"Multiple sclerosis; Locus (genetics); Neuroscience; Psychology; Resilience (materials science); Biology; Genetics; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004234443,0.000115096,0.0002949037,0.0002018694,0.00007286147,0.000007371033,0.0001546596,0.0004720967,0.000009680743],"category_scores_gemma":[0.002962014,0.00008633953,0.0000878492,0.000837298,0.0001238986,0.00005922714,0.0001535575,0.0008559604,0.00001019674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006176136,"about_ca_system_score_gemma":0.00006061374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004091369,"about_ca_topic_score_gemma":0.00009918975,"domain_scores_codex":[0.9986607,0.00003070155,0.00021885,0.000310488,0.0004118604,0.0003673433],"domain_scores_gemma":[0.9988999,0.000431183,0.00006008227,0.0002913017,0.0002322868,0.00008518952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009037607,0.0002940821,0.4445373,0.0008411771,0.00004503687,0.000007969594,0.0005901034,0.00002453828,0.4412621,0.00003988447,0.02995959,0.08149445],"study_design_scores_gemma":[0.001895802,0.0001818813,0.9077654,0.0005132679,0.000008863132,0.000001082448,0.0002291903,0.002063083,0.08474839,0.00008213826,0.00242281,0.00008811655],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936019,0.000962308,0.00001477637,0.003622881,0.00007710177,0.001328221,0.00009785197,0.00009830002,0.000196672],"genre_scores_gemma":[0.9975287,0.0005651478,0.001293182,0.00011058,0.00006402859,0.0002415377,0.00003863792,0.00001679944,0.0001414003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.463228,"threshold_uncertainty_score":0.371877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06054588484409179,"score_gpt":0.3783048962027753,"score_spread":0.3177590113586835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}