{"id":"W4382395320","doi":"10.1093/neuonc/noad114","title":"Clinical outcome of pediatric medulloblastoma patients with Li–Fraumeni syndrome","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institute of Neurological Disorders and Stroke; Helse Sør-Øst RHF; University of California, San Francisco; Deutschen Konsortium für Translationale Krebsforschung; Université de Recherche Paris Sciences et Lettres; Norges Forskningsråd; Institut Gustave-Roussy; Deutsche Kinderkrebsstiftung; Universitätsklinikum Hamburg-Eppendorf; Making Headway Foundation; Universitätsklinikum Heidelberg; Université Paris-Saclay; Universitetet i Oslo; Bundesministerium für Bildung und Forschung; Hospital for Sick Children; State Government of Victoria; Brain Tumour Research; Institut National de la Santé et de la Recherche Médicale; Bundesamt für Gesundheit; Brain Tumour Charity; Deutsches Krebsforschungszentrum; Centre National de la Recherche Scientifique; Robert Connor Dawes Foundation; Cancer Australia; National Institutes of Health; Friedberg Charitable Foundation; Cancer Research UK; Eli Lilly and Company; Y-mAbs Therapeutics","keywords":"Li–Fraumeni syndrome; Medulloblastoma; Outcome (game theory); Medicine; Pediatrics; Oncology; Cancer research; Mutation; Genetics; Germline mutation; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002552558,0.0002804323,0.0003185017,0.0007085641,0.0003222309,0.0003338887,0.0002306364,0.0002143733,0.0008029664],"category_scores_gemma":[0.0009359072,0.0001340216,0.0002249185,0.0005061315,0.0002609581,0.000279334,0.0003209328,0.0002250313,0.0001500306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003670589,"about_ca_system_score_gemma":0.0003229115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002044688,"about_ca_topic_score_gemma":0.001885054,"domain_scores_codex":[0.9998211,0.00003063173,0.00002191277,0.00004908933,0.00003340419,0.00004389688],"domain_scores_gemma":[0.9993262,0.00008699004,0.0003914007,0.00002813749,0.00003947516,0.0001278189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001393934,0.00001120693,0.9971097,0.000005249977,0.00001594303,0.0008811461,0.00004989836,0.00005947793,0.0006136552,0.000008452192,0.00004252528,0.001063362],"study_design_scores_gemma":[0.000007344077,0.0001635695,0.9929988,0.00000412848,0.00002890767,0.006144239,0.0001224369,0.0001335354,0.0002099167,0.0000180295,0.0001656913,0.000003276435],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995645,0.0001322042,0.00002885163,0.00000859584,0.000001036326,0.000003194715,0.0001417654,0.000002409886,0.0001173492],"genre_scores_gemma":[0.999577,0.00007908253,0.00003867345,0.00000395553,0.000003014447,0.00000481043,0.0002703378,0.000001299509,0.00002197748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002044688,"threshold_uncertainty_score":0.004065573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03179412279404297,"score_gpt":0.336701827633021,"score_spread":0.3049077048389781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}