{"id":"W4382395320","doi":"10.1093/neuonc/noad114","title":"Clinical outcome of pediatric medulloblastoma patients with Li–Fraumeni syndrome","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institute of Neurological Disorders and Stroke; Helse Sør-Øst RHF; University of California, San Francisco; Deutschen Konsortium für Translationale Krebsforschung; Université de Recherche Paris Sciences et Lettres; Norges Forskningsråd; Institut Gustave-Roussy; Deutsche Kinderkrebsstiftung; Universitätsklinikum Hamburg-Eppendorf; Making Headway Foundation; Universitätsklinikum Heidelberg; Université Paris-Saclay; Universitetet i Oslo; Bundesministerium für Bildung und Forschung; Hospital for Sick Children; State Government of Victoria; Brain Tumour Research; Institut National de la Santé et de la Recherche Médicale; Bundesamt für Gesundheit; Brain Tumour Charity; Deutsches Krebsforschungszentrum; Centre National de la Recherche Scientifique; Robert Connor Dawes Foundation; Cancer Australia; National Institutes of Health; Friedberg Charitable Foundation; Cancer Research UK; Eli Lilly and Company; Y-mAbs Therapeutics","keywords":"Li–Fraumeni syndrome; Medulloblastoma; Outcome (game theory); Medicine; Pediatrics; Oncology; Cancer research; Mutation; Genetics; Germline mutation; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003656686,0.0002236437,0.0008510568,0.0003720211,0.00004258671,0.000004066291,0.0001861178,0.0003769369,0.0001395593],"category_scores_gemma":[0.0007260168,0.0001877695,0.0002054427,0.0009683335,0.0001770176,0.00004307759,0.0001597675,0.0006843282,0.0004865829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524841,"about_ca_system_score_gemma":0.0004262239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001350234,"about_ca_topic_score_gemma":0.00001815515,"domain_scores_codex":[0.9974372,0.000220198,0.0008772715,0.0005198107,0.0004892577,0.000456266],"domain_scores_gemma":[0.9980389,0.0005608993,0.0003605658,0.0005439696,0.0002005882,0.0002950697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009406776,0.0008106955,0.9787726,0.0001180419,0.0001341118,0.002185788,0.0001060318,0.00004341649,0.002635178,0.00003049265,0.006832334,0.007390573],"study_design_scores_gemma":[0.01143966,0.01748816,0.9299516,0.00003113098,0.0006663664,0.0004062682,0.00003740797,0.0001235921,0.0005070906,0.00002436695,0.03905394,0.0002703787],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951214,0.00004858409,0.00003845849,0.0008387451,0.001474267,0.0007148202,0.00002811531,0.00021876,0.001516833],"genre_scores_gemma":[0.9979923,0.0001048577,0.0003215678,0.001078843,0.0002226007,0.00004482149,0.00004836272,0.00007583133,0.000110756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04882102,"threshold_uncertainty_score":0.7657018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03179412279404297,"score_gpt":0.336701827633021,"score_spread":0.3049077048389781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}