{"id":"W4382396967","doi":"10.1136/ijgc-2023-004491","title":"A phase I study of the Wee1 kinase inhibitor adavosertib (AZD1775) in combination with chemoradiation in cervical, upper vaginal, and uterine cancers","year":2023,"lang":"en","type":"article","venue":"International Journal of Gynecological Cancer","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre","funders":"MorphoSys; Eisai; National Cancer Institute; Novocure; Regeneron Pharmaceuticals; Seagen; Gilead Sciences; AstraZeneca; Pfizer; Amgen","keywords":"Medicine; Cervical cancer; Endometrial cancer; Toxicity; Clinical endpoint; Internal medicine; External beam radiotherapy; Urology; Mucositis; Wee1; Cisplatin; Oncology; Radiation therapy; Clinical trial; Surgery; Cancer; Brachytherapy; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000765114,0.001062708,0.002018678,0.0005095119,0.000412555,0.0009276575,0.0009197714,0.0008752092,0.002995281],"category_scores_gemma":[0.0004351259,0.0005040901,0.001497885,0.0005308459,0.0008144695,0.0006794698,0.0002880904,0.002990939,0.0005969891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008906594,"about_ca_system_score_gemma":0.001685789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002290595,"about_ca_topic_score_gemma":0.006412516,"domain_scores_codex":[0.9997787,0.0000696003,0.0000108627,0.00004187977,0.00002392433,0.00007504409],"domain_scores_gemma":[0.9997824,0.00003415377,0.00002764564,0.0000237436,0.00001499314,0.0001171118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4902356,0.1206613,0.004390248,0.002305941,0.003610143,0.0003887574,0.0004763078,0.006332516,0.1151814,0.001056752,0.006678886,0.2486822],"study_design_scores_gemma":[0.3723395,0.5931719,0.008871972,0.00008347769,0.001234531,0.000416706,0.0001794175,0.002407208,0.01314529,0.0003657077,0.007734128,0.00005019792],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887033,0.005517289,0.0005823341,0.0004453254,0.0002556833,0.00156081,0.0006730212,0.0001059187,0.002156344],"genre_scores_gemma":[0.9851362,0.006208502,0.001737947,0.0005979721,0.0001491811,0.001370825,0.001531602,0.00003321435,0.003234636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002995281,"threshold_uncertainty_score":0.0100202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02871940459984262,"score_gpt":0.3524805468404295,"score_spread":0.3237611422405869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}