{"id":"W4382459108","doi":"10.3389/fnmol.2023.1191323","title":"Bridging the translational gap: what can synaptopathies tell us about autism?","year":2023,"lang":"en","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Centre for Addiction and Mental Health","funders":"Innovative Medicines Initiative; Science Foundation Ireland; Autism Speaks; Simons Foundation Autism Research Initiative; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; European Commission","keywords":"Neuroscience; Autism; Glutamatergic; Biology; Neurotransmission; GABAergic; Psychology; Inhibitory postsynaptic potential; Glutamate receptor; Psychiatry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01143788,0.001387143,0.003451612,0.003154852,0.001909171,0.005321619,0.002400616,0.008584491,0.008253955],"category_scores_gemma":[0.02390516,0.0006253499,0.00169952,0.001623141,0.006847354,0.01801099,0.004941323,0.01430564,0.003441484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002684836,"about_ca_system_score_gemma":0.006084145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002781383,"about_ca_topic_score_gemma":0.004169975,"domain_scores_codex":[0.9976844,0.0009769276,0.0003395034,0.0003289227,0.0004473976,0.0002228457],"domain_scores_gemma":[0.9763554,0.01724865,0.000931137,0.0009439841,0.002888438,0.001632394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008379537,0.0001432016,0.003476874,0.01930577,0.0005345443,0.001797061,0.0023723,0.0006101547,0.001996798,0.06551726,0.2282495,0.6751586],"study_design_scores_gemma":[0.00008464709,0.0003305362,0.003259284,0.02098423,0.0003935117,0.003018904,0.003987146,0.0003799698,0.0007125859,0.2619448,0.704747,0.0001573876],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006948266,0.7993727,0.001128849,0.1901618,0.006398653,0.00001146233,0.0002093379,0.00006604734,0.001956296],"genre_scores_gemma":[0.009888702,0.9183705,0.001625458,0.0534092,0.01526428,0.00005784151,0.0002702795,0.00004930058,0.001064404],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01143788,"threshold_uncertainty_score":0.06049001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05964906727663871,"score_gpt":0.3314841182498305,"score_spread":0.2718350509731918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}