{"id":"W4382459108","doi":"10.3389/fnmol.2023.1191323","title":"Bridging the translational gap: what can synaptopathies tell us about autism?","year":2023,"lang":"en","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Centre for Addiction and Mental Health","funders":"Innovative Medicines Initiative; Science Foundation Ireland; Autism Speaks; Simons Foundation Autism Research Initiative; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; European Commission","keywords":"Neuroscience; Autism; Glutamatergic; Biology; Neurotransmission; GABAergic; Psychology; Inhibitory postsynaptic potential; Glutamate receptor; Psychiatry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication"],"consensus_categories":[],"category_scores_codex":[0.001020936,0.0007704808,0.00127833,0.001103109,0.0006892157,0.001132903,0.003637266,0.0002930238,0.00001477646],"category_scores_gemma":[0.0009912631,0.0006160036,0.0004496015,0.004668732,0.001697723,0.0006030067,0.0006038192,0.001924396,0.00008478675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002099517,"about_ca_system_score_gemma":0.0009332881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005299924,"about_ca_topic_score_gemma":0.00002228042,"domain_scores_codex":[0.9918454,0.001494606,0.0009505385,0.002128888,0.002003025,0.001577543],"domain_scores_gemma":[0.9977141,0.000386065,0.0003896962,0.001268646,0.00001048151,0.0002310116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000190402,0.0002287526,0.000176239,0.005828976,0.00002507726,0.005445934,0.0008828727,0.001402845,0.001352604,0.01943769,0.001651026,0.963549],"study_design_scores_gemma":[0.0004567731,0.0001374685,0.0004992115,0.007921246,0.0001868032,0.0006218675,0.00006167153,0.01505435,0.0005852013,0.006078157,0.966438,0.001959238],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001124586,0.9807044,0.01061102,0.00187645,0.003871657,0.002170409,0.000127905,0.0002593894,0.0002662592],"genre_scores_gemma":[0.0008507558,0.9969245,0.0001956539,0.0009944878,0.00004948986,0.0003069194,0.00001664485,0.000180412,0.0004811838],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.964787,"threshold_uncertainty_score":0.999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05964906727663871,"score_gpt":0.3314841182498305,"score_spread":0.2718350509731918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}