{"id":"W4382467867","doi":"10.1371/journal.pone.0286887","title":"Outcomes and clinical implications of intranasal insulin on cognition in humans: A systematic review and meta-analysis","year":2023,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Dementia Research Alliance; Diabetes Canada; University of Toronto; Centre for Addiction and Mental Health","funders":"Ontario Ministry of Research and Innovation; Weston Brain Institute; Canadian Institutes of Health Research; HLS Therapeutics; National Institutes of Health; Banting and Best Diabetes Centre, University of Toronto; Department of Psychiatry, University of Toronto; Mitsubishi Tanabe Pharma Corporation; Danish Diabetes Academy; University of Toronto; Physicians' Services Incorporated Foundation; Ontario Ministry of Health and Long-Term Care; Fondation Brain Canada","keywords":"Meta-analysis; Cognition; PsycINFO; Medicine; Randomized controlled trial; MEDLINE; Systematic review; Bioinformatics; Clinical psychology; Internal medicine; Psychiatry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01514648,0.003012674,0.01932925,0.006877739,0.00067715,0.003531138,0.002077613,0.002159654,0.003569174],"category_scores_gemma":[0.03631402,0.00139359,0.03662783,0.007881377,0.0008334066,0.001689276,0.001752293,0.001892244,0.0002624199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003161756,"about_ca_system_score_gemma":0.004344067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007679427,"about_ca_topic_score_gemma":0.01650127,"domain_scores_codex":[0.9894066,0.004730311,0.003347555,0.001016061,0.001205635,0.0002937417],"domain_scores_gemma":[0.9784842,0.01558295,0.003508629,0.0005604776,0.001636428,0.0002273727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00135129,0.00002410594,0.003017197,0.5094681,0.4736232,0.00009241202,0.00008464811,0.0003114442,0.00013499,0.000100833,0.0004762931,0.01131552],"study_design_scores_gemma":[0.0004414589,0.0001675434,0.003433019,0.04065412,0.9535882,0.00008195058,0.00004822154,0.0001063805,0.00008976398,0.0001291197,0.001240332,0.00001990731],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003081537,0.9954826,0.0002997251,0.0001300049,0.00009694515,0.0002805485,0.0004069316,0.00001411719,0.000207708],"genre_scores_gemma":[0.1211378,0.8739737,0.001716437,0.0007213653,0.0002198639,0.001264187,0.0006874144,0.00002447563,0.0002546822],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01932925,"threshold_uncertainty_score":0.08010322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6874290377546968,"score_gpt":0.5575372081876935,"score_spread":0.1298918295670033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}