{"id":"W4382501551","doi":"10.1007/s12325-023-02583-1","title":"DElaying Disease Progression In COPD with Early Initiation of Dual Bronchodilator or Triple Inhaled PharmacoTherapy (DEPICT): A Predictive Modelling Approach","year":2023,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Manchester Biomedical Research Centre; McMaster University; Glenmark Pharmaceuticals; CSL Behring; Gilead Sciences; Sanofi; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Genentech; AstraZeneca","keywords":"Medicine; Fluticasone propionate; COPD; Lama; Indacaterol; Exacerbation; Bronchodilator; Pharmacotherapy; Internal medicine; Obstructive lung disease; Corticosteroid; Asthma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00119086,0.001049705,0.0009754113,0.0006995571,0.0003278127,0.001391508,0.001390047,0.001305272,0.001351215],"category_scores_gemma":[0.003653412,0.0006542229,0.001743647,0.0004847322,0.0004379335,0.0006214032,0.0007280244,0.001070189,0.0002196009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060928,"about_ca_system_score_gemma":0.001226419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01831533,"about_ca_topic_score_gemma":0.00940046,"domain_scores_codex":[0.9996113,0.0001806628,0.00002413326,0.00007255568,0.00004844173,0.00006280729],"domain_scores_gemma":[0.9982104,0.001268218,0.0002651534,0.00005193672,0.0001312969,0.00007306044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001174438,0.00004957898,0.002726481,0.00003716684,0.00004735843,0.0000456345,0.0000391133,0.9920173,0.0005170564,0.0006560626,0.00009220358,0.003654545],"study_design_scores_gemma":[0.0000127214,0.00008441484,0.0007201631,0.000007974606,0.0000358145,0.00002005625,0.00001127525,0.9981517,0.000194874,0.0005997585,0.0001514459,0.000009722497],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7677565,0.001476378,0.2165912,0.002127067,0.0001281981,0.0002996057,0.001285878,0.0006743542,0.009660862],"genre_scores_gemma":[0.9844471,0.0003967238,0.01251157,0.0001248242,0.00002886096,0.0001518481,0.0003464222,0.00002517788,0.001967299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01831533,"threshold_uncertainty_score":0.03641742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633041686003346,"score_gpt":0.3534660540880132,"score_spread":0.3171356372279798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}