{"id":"W4382501648","doi":"10.1242/dev.201534","title":"Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis","year":2023,"lang":"en","type":"article","venue":"Development","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canada Foundation for Innovation; Canadian Institutes of Health Research; Hospital for Sick Children; Autism Speaks","keywords":"Biology; Neurogenesis; Progenitor cell; Hindbrain; Neuroepithelial cell; Sonic hedgehog; Progenitor; Rhombomere; Stem cell; Neuroscience; Lineage (genetic); Cellular differentiation; Cell biology; Neural stem cell; Genetics; Central nervous system; Hox gene; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001899783,0.0003049809,0.0003446233,0.0003531721,0.0003614402,0.00005390208,0.000396817,0.0000736283,0.00007303704],"category_scores_gemma":[0.00007009047,0.0002927469,0.0001087119,0.000875681,0.00005437062,0.00009104943,0.0002309945,0.0001236895,0.0002611641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002895606,"about_ca_system_score_gemma":0.00006222381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005573812,"about_ca_topic_score_gemma":0.000006288887,"domain_scores_codex":[0.9971941,0.0003383947,0.0006182175,0.0007258671,0.0006420237,0.000481429],"domain_scores_gemma":[0.9988826,0.0003197772,0.0002574315,0.000342026,0.00005757139,0.0001405757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002201915,0.0001157894,0.0003712116,0.00004741632,0.000007504042,0.00005837145,0.0003359707,0.00006077139,0.9964891,0.0003285134,0.0001947796,0.001968525],"study_design_scores_gemma":[0.0003906465,0.00009943014,0.01440561,0.00002094566,0.00001606474,0.000007120002,0.00001414287,0.0005338885,0.9830579,0.00004743313,0.001157268,0.0002495231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997948,0.000005760181,0.00008807581,0.00006150032,0.0008592941,0.0003811601,0.00003253273,0.000551297,0.00007236301],"genre_scores_gemma":[0.9986778,0.00006350905,0.00008282899,0.0002034479,0.00004013608,0.00003777149,0.00001274567,0.00007299409,0.0008087066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0140344,"threshold_uncertainty_score":0.9999525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04403777046830156,"score_gpt":0.2446313293679854,"score_spread":0.2005935588996838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}