{"id":"W4382502181","doi":"10.1186/s13578-023-01033-3","title":"Spatiotemporal control of genome engineering in cone photoreceptors","year":2023,"lang":"en","type":"article","venue":"Cell & Bioscience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Alcon Research Institute; Ministry of Science and Technology, Taiwan; National Eye Institute; Foundation Fighting Blindness; National Institutes of Health; Kaohsiung Medical University Chung-Ho Memorial Hospital; Kaohsiung Medical University; Sun Yat-sen University; Irving Medical Center, Columbia University; Research to Prevent Blindness; Eberhard Karls Universität Tübingen; National Cancer Institute; National Sun Yat-sen University","keywords":"Cre recombinase; Visual phototransduction; Biology; Retina; Opsin; Retinal; Achromatopsia; Cell biology; Transducin; Genetics; Computational biology; Neuroscience; Transgene; Gene; Genetically modified mouse; Biochemistry; Rhodopsin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521878,0.00006187577,0.00007159141,0.00007066119,0.00001555911,0.000006493908,0.0001354235,0.00004134366,0.0000120033],"category_scores_gemma":[0.00003787575,0.00006022126,0.00002448013,0.0002846769,0.00006011338,0.000003030304,0.00003709226,0.00002616905,0.0000136335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005464347,"about_ca_system_score_gemma":0.00004410526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001651266,"about_ca_topic_score_gemma":0.000004874332,"domain_scores_codex":[0.999468,0.000007910641,0.0001185645,0.0001637159,0.00008435916,0.0001574978],"domain_scores_gemma":[0.9998184,0.00000600576,0.00003454659,0.00008923661,0.00001847416,0.00003335305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009908507,0.00001115136,0.02650777,0.00001157386,0.000001059786,9.970082e-7,0.000044867,0.0003492551,0.9728784,0.000008376774,0.00008590168,0.00009076919],"study_design_scores_gemma":[0.0007971311,0.0001501708,0.1654095,0.00001027238,0.000001978614,5.62566e-7,0.00007988701,0.002009316,0.8235108,0.00001051171,0.007833158,0.0001867897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984316,0.0001155176,0.0006235264,0.00003449059,0.00008823348,0.00008717879,0.000003443738,0.000008706915,0.0006072687],"genre_scores_gemma":[0.9993758,0.00008656846,0.0001667628,0.00003709905,0.00001250975,0.000005803807,0.00002132681,0.000004853748,0.0002892309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1493676,"threshold_uncertainty_score":0.2455752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004959078648392408,"score_gpt":0.1985239937350749,"score_spread":0.1935649150866825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}