{"id":"W4382502181","doi":"10.1186/s13578-023-01033-3","title":"Spatiotemporal control of genome engineering in cone photoreceptors","year":2023,"lang":"en","type":"article","venue":"Cell & Bioscience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Alcon Research Institute; Ministry of Science and Technology, Taiwan; National Eye Institute; Foundation Fighting Blindness; National Institutes of Health; Kaohsiung Medical University Chung-Ho Memorial Hospital; Kaohsiung Medical University; Sun Yat-sen University; Irving Medical Center, Columbia University; Research to Prevent Blindness; Eberhard Karls Universität Tübingen; National Cancer Institute; National Sun Yat-sen University","keywords":"Cre recombinase; Visual phototransduction; Biology; Retina; Opsin; Retinal; Achromatopsia; Cell biology; Transducin; Genetics; Computational biology; Neuroscience; Transgene; Gene; Genetically modified mouse; Biochemistry; Rhodopsin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401528,0.0003530409,0.0001580704,0.0002512958,0.0001430349,0.0004044595,0.0003145669,0.0003558533,0.000814627],"category_scores_gemma":[0.0001640212,0.0001987796,0.0002942894,0.0001236964,0.0002103924,0.0001619902,0.0003112962,0.0004792963,0.0003172697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000375156,"about_ca_system_score_gemma":0.0002445632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006719035,"about_ca_topic_score_gemma":0.0009407771,"domain_scores_codex":[0.9997659,0.00003199987,0.00002487057,0.00005889675,0.00008104515,0.0000372553],"domain_scores_gemma":[0.9998387,0.0000321682,0.00005980161,0.00002251803,0.00002056678,0.0000261141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001147827,0.000008359729,0.00003026118,0.00001215678,0.00000133823,0.00001510121,0.000007657985,0.000103055,0.9989618,0.0001517759,0.00001551218,0.0006815735],"study_design_scores_gemma":[0.000009331879,0.0000942098,0.0005589239,0.000004168827,0.000007369384,0.00009895283,0.000009952137,0.001223415,0.9944223,0.00005298078,0.003514315,0.000004141209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902565,0.00171115,0.08894793,0.0001385928,0.00009136151,0.000279276,0.0008437195,0.0006553633,0.004767618],"genre_scores_gemma":[0.9592237,0.0009815032,0.03305908,0.0000680321,0.00001302911,0.0001351314,0.0006575075,0.0002669818,0.005594992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000814627,"threshold_uncertainty_score":0.002725184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004959078648392408,"score_gpt":0.1985239937350749,"score_spread":0.1935649150866825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}