{"id":"W4382517901","doi":"10.1200/po.22.00633","title":"Exceptional Response to Bromodomain and Extraterminal Domain Inhibitor Therapy With BMS-986158 in <i>BRD4-NUTM1</i> NUT Carcinoma Harboring a <i>BRD4</i> Splice Site Mutation","year":2023,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute; Daiichi Sankyo Europe; AstraZeneca","keywords":"Bromodomain; Citation; BRD4; Cancer; Library science; Medicine; Cancer research; Internal medicine; Biology; Genetics; Computer science; Gene; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001245393,0.000262729,0.0002957627,0.0003262243,0.0001352751,0.00004216684,0.000178441,0.0003096099,0.00004500012],"category_scores_gemma":[0.0001604396,0.0002358581,0.00006023142,0.0004886296,0.0001113449,0.00002813503,0.0001710634,0.0001963284,0.00006952271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142722,"about_ca_system_score_gemma":0.000267621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004246996,"about_ca_topic_score_gemma":0.0001977108,"domain_scores_codex":[0.9976015,0.0005118804,0.0004536229,0.0007291176,0.0002979276,0.0004059376],"domain_scores_gemma":[0.9990277,0.000173591,0.000143635,0.0003493332,0.0001105608,0.000195205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008285412,0.0001729115,0.003261936,0.0000110149,0.00001288239,0.0001143875,0.0005881205,0.00009471783,0.9672356,0.00002832865,0.00349174,0.01670295],"study_design_scores_gemma":[0.01090242,0.008693831,0.2158168,0.0001520803,0.00001508588,0.000427044,0.0008390019,0.0004229379,0.4220279,0.0004276817,0.339346,0.0009292167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960383,0.0003101992,0.0008803652,0.001386449,0.0002158194,0.0007689352,0.00003287978,0.00004609663,0.0003209898],"genre_scores_gemma":[0.9935265,0.0001587228,0.003979124,0.0008544222,0.0003369165,0.0002895175,0.0001453301,0.00004236435,0.0006671385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5452077,"threshold_uncertainty_score":0.9618012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135709230996631,"score_gpt":0.2839932525883621,"score_spread":0.270422329488699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}