{"id":"W4382517901","doi":"10.1200/po.22.00633","title":"Exceptional Response to Bromodomain and Extraterminal Domain Inhibitor Therapy With BMS-986158 in <i>BRD4-NUTM1</i> NUT Carcinoma Harboring a <i>BRD4</i> Splice Site Mutation","year":2023,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute; Daiichi Sankyo Europe; AstraZeneca","keywords":"Bromodomain; Citation; BRD4; Cancer; Library science; Medicine; Cancer research; Internal medicine; Biology; Genetics; Computer science; Gene; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003755782,0.0004806075,0.0008284947,0.0006292174,0.0005624699,0.0004557812,0.0004550356,0.001285774,0.001426399],"category_scores_gemma":[0.0008841521,0.0001874942,0.0009545971,0.0003941254,0.0003802909,0.0006006783,0.0004632688,0.001843192,0.0008718806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008534441,"about_ca_system_score_gemma":0.0003089787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008156733,"about_ca_topic_score_gemma":0.002145826,"domain_scores_codex":[0.999688,0.0000388017,0.00004129234,0.00005578361,0.00007986261,0.00009637899],"domain_scores_gemma":[0.999328,0.0001588379,0.00007899885,0.00009345635,0.00004023067,0.0003004972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.002821192,0.0005816083,0.03033731,0.0004363953,0.0002694906,0.7669507,0.0002843993,0.002367,0.03959636,0.001497768,0.008197561,0.1466603],"study_design_scores_gemma":[0.0005075825,0.003104465,0.06937176,0.0001359321,0.0003007195,0.8789101,0.0002263773,0.006357577,0.0225561,0.002341871,0.01609877,0.00008872347],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9306965,0.01192423,0.01252603,0.008736091,0.001058983,0.0003492727,0.000905465,0.0009227634,0.03288054],"genre_scores_gemma":[0.9900929,0.001768049,0.001790489,0.002372759,0.0002525786,0.00004657985,0.0006580059,0.00008588877,0.002932633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426399,"threshold_uncertainty_score":0.006192207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135709230996631,"score_gpt":0.2839932525883621,"score_spread":0.270422329488699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}