{"id":"W4382542421","doi":"10.1016/j.str.2023.06.002","title":"Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40","year":2023,"lang":"en","type":"article","venue":"Structure","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Sciex (Canada); Structural Genomics Consortium; University of Toronto","funders":"Janssen Canada; Genentech; Innovative Medicines Initiative; Ontario Genomics Institute; National Institutes of Health; Ontario Genomics; Merck KGaA; Genome Canada; CHDI Foundation; Bayer; Pfizer; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceutical Company; Bristol-Myers Squibb; Innovative Health Initiative; McGill University; Boehringer Ingelheim; Massachusetts General Hospital; Huntington's Disease Society of America","keywords":"Huntingtin; Protein–protein interaction; Computational biology; Scaffold protein; Function (biology); Biology; Protein function; Chemistry; Cell biology; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370144,0.0002555526,0.000181824,0.0002383994,0.0002285309,0.0002029703,0.0002703518,0.0002331418,0.001114003],"category_scores_gemma":[0.0002109639,0.0001313426,0.00027507,0.0001627055,0.0002086413,0.0002265119,0.0001924081,0.0003447168,0.0002864613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242599,"about_ca_system_score_gemma":0.0001505638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249427,"about_ca_topic_score_gemma":0.00118448,"domain_scores_codex":[0.9999465,0.000009301526,0.000004195834,0.00001369964,0.00001134809,0.0000149982],"domain_scores_gemma":[0.9998522,0.00005030742,0.00002809019,0.00001443096,0.00002083082,0.00003409841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003243909,0.00003898038,0.001511319,0.00003574071,0.00001259816,0.0002490068,0.00008946122,0.0002006185,0.995702,0.0004302088,0.00005499721,0.001350628],"study_design_scores_gemma":[0.00003539347,0.0003168655,0.08615626,0.00001628653,0.00005188026,0.001605335,0.0003038885,0.006986135,0.8995065,0.0007643048,0.004238172,0.00001894917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973712,0.0004087829,0.001337182,0.00002884463,0.00000549001,0.000008214166,0.0001007216,0.0000101947,0.0007292536],"genre_scores_gemma":[0.9969314,0.0001440562,0.001423307,0.00003431304,0.000003917232,0.00001353569,0.0003839931,0.000005219657,0.001060237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249427,"threshold_uncertainty_score":0.003726721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02271208378314709,"score_gpt":0.2413196901881231,"score_spread":0.218607606404976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}