{"id":"W4382542421","doi":"10.1016/j.str.2023.06.002","title":"Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40","year":2023,"lang":"en","type":"article","venue":"Structure","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Sciex (Canada); Structural Genomics Consortium; University of Toronto","funders":"Janssen Canada; Genentech; Innovative Medicines Initiative; Ontario Genomics Institute; National Institutes of Health; Ontario Genomics; Merck KGaA; Genome Canada; CHDI Foundation; Bayer; Pfizer; European Federation of Pharmaceutical Industries and Associations; Takeda Pharmaceutical Company; Bristol-Myers Squibb; Innovative Health Initiative; McGill University; Boehringer Ingelheim; Massachusetts General Hospital; Huntington's Disease Society of America","keywords":"Huntingtin; Protein–protein interaction; Computational biology; Scaffold protein; Function (biology); Biology; Protein function; Chemistry; Cell biology; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002667653,0.0000751941,0.00008270313,0.00007536008,0.00004349966,0.000008182602,0.00004384327,0.00002150138,0.00004246198],"category_scores_gemma":[0.0001746349,0.00005268651,0.00001752541,0.0002487313,0.00008466763,0.0000586585,0.00002507146,0.0000550055,9.363143e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004363783,"about_ca_system_score_gemma":0.00002649597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000479788,"about_ca_topic_score_gemma":0.00001577902,"domain_scores_codex":[0.9994478,0.0000525995,0.0001160413,0.000178651,0.0001309097,0.00007402628],"domain_scores_gemma":[0.999656,0.00005100769,0.0001065252,0.00009707481,0.00006786119,0.00002150101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006605925,0.000006990494,0.002515296,0.00002773675,0.000002512384,4.478886e-7,0.0001412658,0.00118022,0.9944395,0.0004382099,0.00003173416,0.001150067],"study_design_scores_gemma":[0.0001893891,0.00007806568,0.05217234,0.00001655376,0.000004188091,0.000004718334,0.0001410761,0.001153868,0.945627,0.0005165128,0.00005130022,0.00004494806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987929,0.000005114498,0.000720689,0.00008375821,0.0000631992,0.0001811502,0.00008170655,0.00002269972,0.00004872261],"genre_scores_gemma":[0.9996772,0.00000159111,0.0001372441,0.000032723,0.00003340889,0.000006523279,0.00001307762,0.000008751092,0.00008949862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04965704,"threshold_uncertainty_score":0.2148494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02271208378314709,"score_gpt":0.2413196901881231,"score_spread":0.218607606404976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}