{"id":"W4382601575","doi":"10.1371/journal.ppat.1011485","title":"Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; McMaster University; Robarts Clinical Trials; McMaster University Medical Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Virology; Peripheral blood mononuclear cell; Viral replication; CD8; Influenza A virus; Immunology; Attenuated vaccine; Virus; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119985,0.0005018564,0.0002712609,0.0002272563,0.00009112186,0.0002097757,0.0001520035,0.0002830046,0.001056453],"category_scores_gemma":[0.00008567241,0.0001048694,0.0001651886,0.00006669077,0.0001916872,0.0002424611,0.0001525599,0.0006801611,0.000264026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177748,"about_ca_system_score_gemma":0.0001290875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000152412,"about_ca_topic_score_gemma":0.0003165133,"domain_scores_codex":[0.999871,0.00002082002,0.00000970717,0.00003197501,0.00002056572,0.00004585966],"domain_scores_gemma":[0.9999143,0.000008725462,0.00002965954,0.000007663504,0.000007219099,0.00003236629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00029143,0.00006974125,0.0001121472,0.00002874077,0.000002740378,0.00001650681,0.000008479905,0.00005961447,0.9966624,0.00005027914,0.00003293084,0.002665128],"study_design_scores_gemma":[0.00004265171,0.003209102,0.002231319,0.000006292134,0.00002948391,0.0001782608,0.00001846739,0.0005423619,0.9919119,0.00003870463,0.001786691,0.000004674696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994525,0.001631831,0.002235887,0.0001050298,0.00003885266,0.00003262033,0.0001738733,0.0001581826,0.001098732],"genre_scores_gemma":[0.9948318,0.0008486445,0.001961455,0.00006083168,0.00002158546,0.00003044284,0.0001749677,0.00001821756,0.00205198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056453,"threshold_uncertainty_score":0.003534198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280762316246171,"score_gpt":0.2112278795137602,"score_spread":0.1984202563512985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}