{"id":"W4382632312","doi":"10.1186/s41181-023-00197-0","title":"First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs","year":2023,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"KWF Kankerbestrijding","keywords":"DOTA; Radionuclide therapy; Alpha (finance); BETA (programming language); Medicine; Nuclear medicine; Chemistry; Chelation; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003386275,0.0005890157,0.0005767616,0.0002354589,0.0001432916,0.0004192351,0.000281886,0.0003698716,0.002106736],"category_scores_gemma":[0.0001986479,0.0002074928,0.0002796617,0.0001924999,0.0002106895,0.0002684841,0.0001111971,0.0007476339,0.0005020835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003806402,"about_ca_system_score_gemma":0.0003206463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211215,"about_ca_topic_score_gemma":0.00149165,"domain_scores_codex":[0.9998792,0.00002757753,0.000007151264,0.0000255573,0.00002572279,0.00003467658],"domain_scores_gemma":[0.9998742,0.00002427906,0.0000307544,0.00001107915,0.00002315008,0.00003656772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003224677,0.0009811772,0.0002710589,0.0003258121,0.00005403133,0.0001050111,0.00005067426,0.001641252,0.9810984,0.0002339394,0.0007167286,0.01129722],"study_design_scores_gemma":[0.0002395981,0.02905149,0.002429161,0.00002256345,0.0001827661,0.0002916197,0.00004574777,0.003259764,0.957212,0.00006849364,0.007175376,0.00002137128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832904,0.004902041,0.005283733,0.0001890857,0.000152561,0.0003256674,0.001192699,0.000194334,0.004469467],"genre_scores_gemma":[0.9849339,0.003332932,0.003300397,0.0000668243,0.00003741315,0.0001441821,0.001038338,0.00005471024,0.007091329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002106736,"threshold_uncertainty_score":0.007047713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1129091092783236,"score_gpt":0.4286358039481039,"score_spread":0.3157266946697804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}