{"id":"W4382678789","doi":"10.1152/ajpheart.00505.2022","title":"Chronic testosterone deficiency increases late inward sodium current and promotes triggered activity in ventricular myocytes from aging male mice","year":2023,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Libin Cardiovascular Institute of Alberta; Dalhousie University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Research Nova Scotia; Heart and Stroke Foundation of Canada; Killam Trusts; Dalhousie University; Government of Canada; Dalhousie Medical Research Foundation","keywords":"Internal medicine; Endocrinology; Afterdepolarization; Testosterone (patch); Ranolazine; Medicine; Sodium channel; Myocyte; Repolarization; Chemistry; Electrophysiology; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574587,0.0003488937,0.0003170699,0.0004405164,0.0001713371,0.0003670728,0.0002436128,0.0003064884,0.002049383],"category_scores_gemma":[0.0001380657,0.0002083085,0.0004245744,0.0002212849,0.000303851,0.0002296919,0.0001864583,0.0006559645,0.0003832145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854725,"about_ca_system_score_gemma":0.0001696544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007570346,"about_ca_topic_score_gemma":0.001492923,"domain_scores_codex":[0.9998153,0.00003025044,0.0000260031,0.0000330555,0.00004941614,0.00004602042],"domain_scores_gemma":[0.9997413,0.0000198705,0.00008770679,0.0000188593,0.00001416196,0.0001181646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005189506,0.00008304587,0.0006801511,0.00003511819,0.00001182773,0.0001027252,0.00003723258,0.00003139172,0.9972693,0.0000649829,0.00006622168,0.001099093],"study_design_scores_gemma":[0.0003588408,0.004573842,0.08418684,0.00004213604,0.0001802641,0.0009704978,0.0003732062,0.001665381,0.9023216,0.0002364651,0.005057816,0.00003306192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962612,0.001241151,0.001162783,0.0001400744,0.00007480317,0.00001195788,0.0004329385,0.00006092339,0.0006141241],"genre_scores_gemma":[0.9940825,0.001134102,0.0006468617,0.0001177986,0.00004423734,0.00004013017,0.0004373783,0.00002896776,0.00346811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049383,"threshold_uncertainty_score":0.006855905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01118083964682056,"score_gpt":0.254849844837277,"score_spread":0.2436690051904565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}