{"id":"W4382698979","doi":"10.1101/2023.06.29.547108","title":"<i>Vibrio cholerae</i> Arrests Intestinal Epithelial Proliferation through T6SS-dependent Activation of the Bone Morphogenetic Protein Pathway","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Directorate for Biological Sciences","keywords":"Vibrio cholerae; Biology; Progenitor cell; Intestinal epithelium; Bone morphogenetic protein; Cell biology; Immune system; Microbiology; Zebrafish; Innate immune system; Epithelium; Immunology; Stem cell; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009644623,0.0002333914,0.0001574194,0.0001093706,0.0001010663,0.0002866821,0.0001368167,0.0002201204,0.00217917],"category_scores_gemma":[0.00008000594,0.00009559879,0.0002005174,0.00007992748,0.0002506724,0.0001045707,0.0002043155,0.0005046437,0.0008900932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000395522,"about_ca_system_score_gemma":0.0002602626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002051192,"about_ca_topic_score_gemma":0.002121067,"domain_scores_codex":[0.9998988,0.00001200509,0.000006697599,0.00001634414,0.00003362554,0.00003254788],"domain_scores_gemma":[0.9999559,0.000005707525,0.00001229462,0.000008262641,0.000006345188,0.00001148171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004477618,0.000006826422,0.00006508642,0.00001886339,0.000001432583,0.00001820391,0.00000353739,0.00003394199,0.9993533,0.00009315537,0.00009968326,0.000261103],"study_design_scores_gemma":[0.00001030598,0.00007034782,0.003086013,0.000005761776,0.000003265248,0.00008957571,0.00002414045,0.0006018826,0.9925943,0.00006534957,0.003446245,0.000002850888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977854,0.002187429,0.006671895,0.0007725754,0.0001660776,0.0000416442,0.002194701,0.0003606262,0.009751071],"genre_scores_gemma":[0.9844141,0.0009486895,0.002521331,0.0002279075,0.00002098706,0.00002839114,0.001586893,0.00008559501,0.010166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00217917,"threshold_uncertainty_score":0.007290065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037383385383237,"score_gpt":0.2409825631771849,"score_spread":0.2206087293233525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}