{"id":"W4382700158","doi":"10.1186/s13062-023-00390-w","title":"Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease","year":2023,"lang":"en","type":"article","venue":"Biology Direct","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Renji Hospital; Shanghai Hospital Development Center; Universidade de Macau; National Natural Science Foundation of China","keywords":"Biology; Bicuspid aortic valve; Mesenchymal stem cell; Macrophage; Stromal cell; Aortic valve; Cell type; Phenotype; Cell; Transcriptome; Population; Calcification; Cell biology; Immunology; In vitro; Pathology; Cancer research; Genetics; Gene; Internal medicine; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003749339,0.0002085844,0.0002446895,0.0002041965,0.0000804669,0.00002281694,0.0001439992,0.0002120249,0.00001207572],"category_scores_gemma":[0.0001008991,0.0002076792,0.0001554876,0.0003731444,0.0001393021,0.000004886805,0.00008882488,0.0001309797,0.00006404646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003547882,"about_ca_system_score_gemma":0.00005763226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004207831,"about_ca_topic_score_gemma":0.0001107213,"domain_scores_codex":[0.9981344,0.000315067,0.0002555675,0.0006518549,0.00009777123,0.0005453597],"domain_scores_gemma":[0.9992551,0.00004696246,0.00002572837,0.00032739,0.00004533931,0.0002994319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001980387,0.00009308626,0.0225213,0.00006784935,0.00002487755,0.00003728742,0.00006465503,0.00002349249,0.9733016,0.000003662465,0.0001189841,0.0035452],"study_design_scores_gemma":[0.001359347,0.001046177,0.1271576,0.00003968339,0.0000553303,0.00001215744,0.00005700089,0.0007294663,0.8631943,0.0001621991,0.005556763,0.0006298635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963205,0.002267824,0.0001604145,0.0001779217,0.0001498805,0.0004977918,0.0001645575,0.00004511185,0.0002159365],"genre_scores_gemma":[0.9987831,0.0002204669,0.00006165748,0.0001606461,0.0001018687,0.00007543821,0.0003168195,0.00003334143,0.0002466302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1101072,"threshold_uncertainty_score":0.8468911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0212648247674169,"score_gpt":0.2849194837890779,"score_spread":0.263654659021661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}