{"id":"W4382721605","doi":"10.3390/v15071470","title":"Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Enhancer; Activator (genetics); Transcription factor; Gene; Molecular biology; Transcription (linguistics); Gene expression; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139457,0.0005337223,0.0003024314,0.0004689961,0.0002908344,0.0006073068,0.0002230088,0.0003314969,0.00307297],"category_scores_gemma":[0.0003104607,0.0002637045,0.0002839681,0.0001992528,0.000289509,0.0002658321,0.0005715071,0.0006738346,0.001155712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006400653,"about_ca_system_score_gemma":0.0003299768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027713,"about_ca_topic_score_gemma":0.001791744,"domain_scores_codex":[0.999775,0.00001970089,0.00001491829,0.0000515742,0.00006748518,0.00007135895],"domain_scores_gemma":[0.9997674,0.00002402363,0.00006158488,0.00002118695,0.0000300393,0.00009580471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001328479,0.0000156162,0.0006697286,0.00002960246,0.000002929173,0.00005596405,0.00001318847,0.00006217472,0.9974267,0.0001314903,0.0001193215,0.001340463],"study_design_scores_gemma":[0.00004315572,0.0001702727,0.05802408,0.00003777871,0.00002642331,0.0004718605,0.0001442912,0.002638284,0.9305808,0.0005215131,0.007318027,0.00002360284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878824,0.005182707,0.002250909,0.0001523637,0.00005675657,0.00003509339,0.001285934,0.0004370637,0.002716845],"genre_scores_gemma":[0.9940633,0.0007348488,0.001229131,0.00007797313,0.00002027567,0.00003311435,0.001359723,0.00008242943,0.002399124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00307297,"threshold_uncertainty_score":0.01028013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06622710457754219,"score_gpt":0.2886409979474163,"score_spread":0.2224138933698741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}