{"id":"W4382723404","doi":"10.3390/v15071472","title":"Modulation of Reoviral Cytolysis (I): Combination Therapeutics","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Oncolytic virus; Paclitaxel; In vivo; Irinotecan; Combination therapy; Cancer research; Docetaxel; Cytotoxicity; Pharmacology; Cancer cell; Cancer; Camptothecin; In vitro; Apoptosis; Cytolysis; Cell culture; Medicine; Biology; Colorectal cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003046249,0.0006228081,0.0007143969,0.0004612058,0.0001115468,0.0005376111,0.0003482029,0.0003398826,0.0007870724],"category_scores_gemma":[0.0001565384,0.0001492203,0.0004586667,0.0002703734,0.0002449768,0.0003929166,0.0002323722,0.0007224355,0.0002341008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003584539,"about_ca_system_score_gemma":0.000210605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002833158,"about_ca_topic_score_gemma":0.0006965267,"domain_scores_codex":[0.9997876,0.00005481885,0.00001596328,0.00004094973,0.00004371211,0.0000569565],"domain_scores_gemma":[0.9999102,0.00001562085,0.00002454834,0.00002004827,0.00001112879,0.00001839483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001053591,0.0006602469,0.0008153777,0.000261877,0.00008109245,0.00008844677,0.00004052951,0.0006929247,0.9541661,0.0002692495,0.0002821153,0.0415885],"study_design_scores_gemma":[0.0003053187,0.01010546,0.00452794,0.00003229109,0.0001968008,0.0004933395,0.00003206169,0.002049259,0.9748492,0.0001158122,0.007273958,0.00001851985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673877,0.01914472,0.008012192,0.000270401,0.0001534168,0.0003039557,0.0002792025,0.0002359222,0.00421248],"genre_scores_gemma":[0.9909395,0.004287918,0.00319265,0.00006792678,0.00004237473,0.00009932895,0.0001985375,0.00002224752,0.001149461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007870724,"threshold_uncertainty_score":0.002633035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05282187235678301,"score_gpt":0.3442073839648187,"score_spread":0.2913855116080357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}