{"id":"W4382751362","doi":"10.1126/sciadv.ade6308","title":"<i>N</i> -acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre; Hospital for Sick Children; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research","keywords":"Skeletal muscle; Myopathy; Dystroglycan; Zebrafish; Sialic acid; Mitochondrial myopathy; Biology; Glycolysis; Regeneration (biology); Muscular dystrophy; Cell biology; Biochemistry; Internal medicine; Chemistry; Endocrinology; Laminin; Medicine; Genetics; Gene; Metabolism; Extracellular matrix; Mitochondrial DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363257,0.0004781769,0.0001758156,0.0002002417,0.0001619697,0.0003304702,0.0002730221,0.0002723495,0.0008907663],"category_scores_gemma":[0.000134713,0.0001588507,0.0001896445,0.0001176496,0.0004869565,0.0001757955,0.0003350255,0.0003424139,0.0004494315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345041,"about_ca_system_score_gemma":0.0001785629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007443722,"about_ca_topic_score_gemma":0.001106692,"domain_scores_codex":[0.9998522,0.00003315687,0.00001542483,0.00004465469,0.00002906119,0.00002550088],"domain_scores_gemma":[0.9998098,0.00001549511,0.00009480191,0.00002087807,0.000011973,0.00004715997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007651385,0.000005397942,0.0002045064,0.000008740168,0.000001951408,0.00006225933,0.000006271488,0.00002748657,0.9990707,0.00007897971,0.00002116643,0.0004361366],"study_design_scores_gemma":[0.00002076324,0.0001062275,0.007729701,0.000007367622,0.00001192836,0.0006684301,0.00003132053,0.001027803,0.9883659,0.0001049062,0.001920004,0.000005820143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925243,0.0006231898,0.004450404,0.00012912,0.00002578261,0.00001628194,0.000375721,0.0001568425,0.001698397],"genre_scores_gemma":[0.9957851,0.0003610229,0.001938405,0.00003791566,0.000007395808,0.00001571353,0.0002967989,0.00005765431,0.001499931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008907663,"threshold_uncertainty_score":0.002979875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007598476087423651,"score_gpt":0.264941586528524,"score_spread":0.2573431104411003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}