{"id":"W4382752997","doi":"10.3390/v15071483","title":"A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Perelman School of Medicine, University of Pennsylvania; University of Pennsylvania; BioNTech","keywords":"Virology; Immunology; Medicine; HSL and HSV; DNA vaccination; Sex organ; Vaccine efficacy; CD8; Herpes simplex virus; Antibody; Antigen; Virus; Biology; Vaccination; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000357575,0.0003769957,0.0005426873,0.0005272368,0.0004949907,0.000150862,0.00009827728,0.0001586024,0.00004848896],"category_scores_gemma":[0.0002517782,0.0002882411,0.0001313267,0.001061724,0.00005725076,0.0002761512,0.0001200732,0.0003406853,0.0003873157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766699,"about_ca_system_score_gemma":0.00009725967,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008753908,"about_ca_topic_score_gemma":0.004871998,"domain_scores_codex":[0.9978636,0.0001486187,0.0005641551,0.0006002626,0.000303427,0.0005199196],"domain_scores_gemma":[0.9989519,0.0001857221,0.000148014,0.000383803,0.0001135728,0.0002170338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00169105,0.001404702,0.617914,0.0002587663,0.00108866,0.0002385323,0.00556639,0.002639289,0.3292955,0.00003279451,0.002260126,0.03761022],"study_design_scores_gemma":[0.00788787,0.0009341623,0.8880337,0.0005465935,0.0003806401,0.00006679896,0.0009407614,0.006119473,0.07257334,0.0001528073,0.02168693,0.0006769563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947128,0.0001808419,0.0008289839,0.0007224783,0.0004444456,0.002305858,0.0001189042,0.0003155637,0.0003701607],"genre_scores_gemma":[0.9977118,0.0003046759,0.0002529603,0.0006358048,0.0003721372,0.0004088482,0.00005909557,0.00006784678,0.0001868639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2701197,"threshold_uncertainty_score":0.999957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05421577311292464,"score_gpt":0.3058924352768257,"score_spread":0.2516766621639011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}