{"id":"W4382752997","doi":"10.3390/v15071483","title":"A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Perelman School of Medicine, University of Pennsylvania; University of Pennsylvania; BioNTech","keywords":"Virology; Immunology; Medicine; HSL and HSV; DNA vaccination; Sex organ; Vaccine efficacy; CD8; Herpes simplex virus; Antibody; Antigen; Virus; Biology; Vaccination; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409926,0.0006031133,0.0003648204,0.0002450081,0.0000817033,0.0002138788,0.0001656193,0.000468368,0.00083327],"category_scores_gemma":[0.0001046517,0.0001485059,0.0002323492,0.00009897042,0.0002020079,0.0002709869,0.0001702288,0.000643085,0.0002009967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022283,"about_ca_system_score_gemma":0.0001941676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00046028,"about_ca_topic_score_gemma":0.0006712429,"domain_scores_codex":[0.9998531,0.00001826516,0.000009864129,0.00003912405,0.00004188972,0.00003777321],"domain_scores_gemma":[0.999938,0.000008099824,0.00001882483,0.000006241511,0.0000109676,0.00001781446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021665,0.00004779314,0.00005914619,0.00003165432,0.000004347071,0.0000144895,0.000006591991,0.0000842012,0.9983745,0.00003133935,0.00002917607,0.001214632],"study_design_scores_gemma":[0.00003927598,0.002595278,0.001343397,0.000008957587,0.0000332644,0.0001809297,0.00001664141,0.0008900857,0.9932652,0.00003167577,0.001589227,0.00000604895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918801,0.001217469,0.004944425,0.0001115146,0.00006045214,0.0000555726,0.0001773432,0.0001428086,0.001410324],"genre_scores_gemma":[0.9889868,0.001243829,0.005286732,0.0001044084,0.00002705906,0.0000854084,0.0005222341,0.00003598543,0.003707431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00083327,"threshold_uncertainty_score":0.00278759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05421577311292464,"score_gpt":0.3058924352768257,"score_spread":0.2516766621639011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}