{"id":"W4382776046","doi":"10.1016/j.celrep.2023.112708","title":"Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health, Pakistan; National Institute of Diabetes and Digestive and Kidney Diseases; Klarman Cell Observatory, Broad Institute; National Institute of Allergy and Infectious Diseases; McMaster University; Broad Institute; Washington University in St. Louis; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Autophagy; Inflammation; Innate immune system; Cell biology; Biology; Cytokine; Downregulation and upregulation; Macrophage; Transcriptome; Context (archaeology); Immune system; Immunology; Gene expression; Gene; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002651764,0.0002383267,0.0003402686,0.0002562433,0.000122419,0.0003440487,0.0001204441,0.0002415919,0.0004101268],"category_scores_gemma":[0.0001053681,0.0001186145,0.0002163934,0.0001351368,0.0004237771,0.0001695703,0.0002174721,0.0005037599,0.0001358893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123046,"about_ca_system_score_gemma":0.000250249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001473628,"about_ca_topic_score_gemma":0.0004692097,"domain_scores_codex":[0.9998191,0.00003603129,0.00001982408,0.00004093293,0.00003619795,0.00004797874],"domain_scores_gemma":[0.9998822,0.00001189584,0.00004492861,0.00001710792,0.0000102459,0.00003352534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002269846,0.0000161022,0.0002059017,0.00002220674,0.000002599879,0.00002217889,0.000007458271,0.000026282,0.998877,0.00004685348,0.00001577814,0.0005307441],"study_design_scores_gemma":[0.00003689044,0.000513882,0.008691671,0.00001038719,0.00002037866,0.0001870279,0.00004174382,0.000553898,0.9886386,0.0001059023,0.001193447,0.000006045284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963793,0.001434263,0.001365491,0.0001125353,0.00002379431,0.00001295879,0.0001868321,0.00006493401,0.0004199816],"genre_scores_gemma":[0.9971669,0.0005288733,0.001449122,0.00005297559,0.00001065413,0.00002711993,0.0001351174,0.00001399522,0.0006151888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004101268,"threshold_uncertainty_score":0.001540422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497484368564832,"score_gpt":0.2694123765395177,"score_spread":0.2544375328538694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}