{"id":"W4382777310","doi":"10.1002/anie.202304977","title":"Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and <i>In Situ</i> Nucleic Acid Complexation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; State Government of Victoria; European Regional Development Fund; RMIT University; Australian Research Council; European Synchrotron Radiation Facility; Australian Synchrotron; Veski; Australian Nuclear Science and Technology Organisation; Ontario Ministry of Natural Resources and Forestry","keywords":"Chemistry; RNA; Endosome; Nucleic acid; Kinetics; Biophysics; Membrane; Crystallography; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507731,0.0001257692,0.0001370374,0.00009993611,0.000043265,0.00003110764,0.0001622566,0.0001260796,0.0001076715],"category_scores_gemma":[0.00009269468,0.0001321538,0.00005362245,0.0001003932,0.00003009704,0.00002742381,0.0001037629,0.00006056807,0.00004227282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005138616,"about_ca_system_score_gemma":0.00006771248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002776787,"about_ca_topic_score_gemma":0.0002157198,"domain_scores_codex":[0.9990741,0.00002445749,0.0002569323,0.0003078921,0.0001989036,0.0001377281],"domain_scores_gemma":[0.9994868,0.00003455655,0.000129077,0.0001484114,0.0001331494,0.00006800245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001292594,0.00006008004,0.001851219,0.00001626374,0.00005856405,0.000004185077,0.0001107124,0.00005583669,0.9791057,0.00002292142,0.01843918,0.0001461081],"study_design_scores_gemma":[0.0007422803,0.00008142681,0.007204696,0.0000309734,0.00001508248,0.000006190576,0.0001257195,0.0002811664,0.9874769,0.0004068768,0.003494865,0.000133845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957974,0.00007976518,0.0002434022,0.0006142937,0.0004026802,0.0001024878,0.0002052413,0.00003770889,0.002516996],"genre_scores_gemma":[0.9932669,0.001200973,0.000152864,0.0002315579,0.0006562019,0.00002115752,0.003930172,0.00001413546,0.0005259907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01494432,"threshold_uncertainty_score":0.5389077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469138312155871,"score_gpt":0.2649102680928886,"score_spread":0.2502188849713299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}