{"id":"W4382777310","doi":"10.1002/anie.202304977","title":"Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and <i>In Situ</i> Nucleic Acid Complexation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; State Government of Victoria; European Regional Development Fund; RMIT University; Australian Research Council; European Synchrotron Radiation Facility; Australian Synchrotron; Veski; Australian Nuclear Science and Technology Organisation; Ontario Ministry of Natural Resources and Forestry","keywords":"Chemistry; RNA; Endosome; Nucleic acid; Kinetics; Biophysics; Membrane; Crystallography; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552949,0.0002152484,0.0001225157,0.00007539221,0.00009024545,0.0002466396,0.0001303507,0.0001866026,0.0005816153],"category_scores_gemma":[0.0001816436,0.0001377853,0.0001273463,0.0001006394,0.0001563919,0.0002154509,0.0001433898,0.0002734984,0.0002450936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002250626,"about_ca_system_score_gemma":0.0001432563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003903106,"about_ca_topic_score_gemma":0.0005260748,"domain_scores_codex":[0.9999067,0.00001474471,0.000007136811,0.0000249963,0.00002676895,0.00001966652],"domain_scores_gemma":[0.999918,0.0000174094,0.00003036161,0.000006891961,0.00001476984,0.00001248342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000418713,0.000006469515,0.00003543208,0.00001073965,0.000001235236,0.000008716142,0.00001463834,0.00005426233,0.9993153,0.00003042117,0.00001205056,0.0004690517],"study_design_scores_gemma":[0.000003120676,0.00003897333,0.000237241,7.393236e-7,0.000001472321,0.00001120779,0.000004787686,0.0008740549,0.9985312,0.000007838617,0.0002870406,0.000002296447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938729,0.0002430563,0.004734353,0.0000364045,0.00001266624,0.0000263916,0.0001153061,0.00007503933,0.0008838447],"genre_scores_gemma":[0.9917568,0.0002873793,0.006061501,0.00003542985,0.000005473989,0.00003939071,0.0001812864,0.00004261454,0.001590114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005816153,"threshold_uncertainty_score":0.001945734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469138312155871,"score_gpt":0.2649102680928886,"score_spread":0.2502188849713299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}