{"id":"W4382796976","doi":"10.1002/ange.202304977","title":"Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and <i>In Situ</i> Nucleic Acid Complexation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; State Government of Victoria; European Regional Development Fund; RMIT University; Australian Research Council; European Synchrotron Radiation Facility; Australian Synchrotron; Veski; Australian Nuclear Science and Technology Organisation; Ontario Ministry of Natural Resources and Forestry","keywords":"Chemistry; RNA; Nucleic acid; Endosome; Kinetics; Biophysics; Ribozyme; Crystallography; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488679,0.0001502128,0.0002065978,0.00005884349,0.00005156674,0.00002342913,0.0001554618,0.0001484339,0.00004778536],"category_scores_gemma":[0.00005109413,0.0001485681,0.00005617912,0.0001422376,0.00003182789,0.00001049302,0.000136537,0.00005870558,0.00004390348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002338688,"about_ca_system_score_gemma":0.00008064607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003195482,"about_ca_topic_score_gemma":0.0003411619,"domain_scores_codex":[0.9990598,0.00002873097,0.0002351506,0.0003492556,0.0001159691,0.0002111202],"domain_scores_gemma":[0.9994534,0.00002753906,0.00009458507,0.0002701416,0.00005763551,0.00009671998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009680259,0.00004447927,0.004125074,0.0000346928,0.00004516367,0.000005627238,0.0001498961,0.00001991488,0.9858869,0.000004335962,0.009475862,0.0001112425],"study_design_scores_gemma":[0.0007227335,0.0001079669,0.004610792,0.00002092555,0.00002272581,0.000004136788,0.0001575605,0.00004709757,0.9909949,0.00009562398,0.003051981,0.0001635064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969242,0.0003834846,0.00001418287,0.0002205109,0.00007093536,0.0001174017,0.00007027932,0.00003898438,0.002159973],"genre_scores_gemma":[0.9960736,0.001891429,0.0001445745,0.0002111774,0.000142239,0.00001308533,0.0007082048,0.00001864263,0.0007970362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006423881,"threshold_uncertainty_score":0.6058431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661267790120975,"score_gpt":0.2573199156856248,"score_spread":0.2407072377844151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}