{"id":"W4382796976","doi":"10.1002/ange.202304977","title":"Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and <i>In Situ</i> Nucleic Acid Complexation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; State Government of Victoria; European Regional Development Fund; RMIT University; Australian Research Council; European Synchrotron Radiation Facility; Australian Synchrotron; Veski; Australian Nuclear Science and Technology Organisation; Ontario Ministry of Natural Resources and Forestry","keywords":"Chemistry; RNA; Nucleic acid; Endosome; Kinetics; Biophysics; Ribozyme; Crystallography; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954779,0.0002249955,0.0001243817,0.00008557681,0.00009628715,0.0002778102,0.0001348622,0.0001960516,0.0006206193],"category_scores_gemma":[0.0002142748,0.0001449595,0.0001274267,0.00009784305,0.0001759421,0.0002100741,0.0001417904,0.0002571837,0.0002364819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002507537,"about_ca_system_score_gemma":0.0001339802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004148093,"about_ca_topic_score_gemma":0.0005028144,"domain_scores_codex":[0.9998975,0.00001906104,0.000007518363,0.00002620481,0.00002830725,0.00002144642],"domain_scores_gemma":[0.9998943,0.00002437764,0.00003753653,0.000009551629,0.00001864441,0.0000156534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003880559,0.000006411755,0.00003411881,0.000009634608,0.000001352785,0.000008026651,0.00001417302,0.00005387705,0.9994633,0.00003015909,0.00001162284,0.0003285891],"study_design_scores_gemma":[0.000003445692,0.00003414842,0.000212289,7.729533e-7,0.000001494261,0.000008988141,0.000004824242,0.001098165,0.9983693,0.000007598665,0.0002567431,0.000002244258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946194,0.0001925459,0.004188971,0.00003212007,0.00001271062,0.0000230468,0.00009359921,0.00007580878,0.0007617517],"genre_scores_gemma":[0.9941021,0.0001631978,0.004201576,0.00002834163,0.000004618096,0.00003140677,0.0001115865,0.00003858919,0.001318643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006206193,"threshold_uncertainty_score":0.002076209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661267790120975,"score_gpt":0.2573199156856248,"score_spread":0.2407072377844151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}