{"id":"W4382797300","doi":"10.1101/2023.06.30.547196","title":"Chemogenetic profiling of ubiquitin-like modifier pathways identifies NFATC2IP as a mediator of SUMO-dependent genome integrity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"SUMO protein; Ubiquitin; Ubiquitin ligase; Biology; Cell biology; Genome; Proteome; CRISPR; Mediator; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200486,0.0001931763,0.0001416626,0.0002767937,0.0002036676,0.0003055076,0.0001708975,0.0002291982,0.001090487],"category_scores_gemma":[0.0001121235,0.00009591491,0.000166299,0.0002561095,0.0001898881,0.0001242337,0.000146372,0.0003441243,0.0003736081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004138738,"about_ca_system_score_gemma":0.0001702796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242448,"about_ca_topic_score_gemma":0.001868331,"domain_scores_codex":[0.9998938,0.00000831287,0.000007711998,0.00002987909,0.00003690047,0.00002326118],"domain_scores_gemma":[0.9998889,0.00002118104,0.00002922546,0.00002060335,0.0000180388,0.00002211783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000262856,0.000007047447,0.0002844593,0.00000496385,0.000001176223,0.00001180918,0.000002921025,0.00002747597,0.9992644,0.00002427448,0.00001491898,0.0003301667],"study_design_scores_gemma":[0.000002355691,0.00002647576,0.006636923,9.56986e-7,0.000003311807,0.00008150046,0.00001057364,0.0005528966,0.9919539,0.00002458397,0.0007049881,0.000001542781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850722,0.0005819121,0.008753444,0.0001219631,0.00002375885,0.00003736723,0.003293542,0.000143551,0.001972276],"genre_scores_gemma":[0.9857913,0.0002621221,0.006869555,0.00005905602,0.000004550594,0.00003063444,0.003282697,0.00004145737,0.003658495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242448,"threshold_uncertainty_score":0.003648102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291373477675398,"score_gpt":0.2434878414341657,"score_spread":0.214350493666626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}