{"id":"W4382799163","doi":"10.1016/j.annonc.2023.04.182","title":"P-126 TROPION-PanTumor03, a phase 2, multicentre study of datopotamab deruxtecan (Dato-DXd) as monotherapy and in combination with anticancer agents in patients with advanced/metastatic solid tumours: Substudies in gastric and colorectal cancer","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Cilag; Loxo Oncology; Chugai Pharmaceutical; Pharmacyclics; Genentech; Aptitude Health; Servier; Eisai; Daiichi-Sankyo; AstraZeneca España; Silverback Therapeutics; Puma Biotechnology; F. Hoffmann-La Roche; Incyte; Mersana Therapeutics; Karyopharm Therapeutics; Sanofi; Spectrum Pharmaceuticals; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Internal medicine; Oncology; Salvage therapy; Phases of clinical research; Solid tumor; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001680597,0.001630479,0.002148253,0.0005460521,0.0003718656,0.0011361,0.000941864,0.0012062,0.00258279],"category_scores_gemma":[0.0009157804,0.00076816,0.002254294,0.0008848849,0.001003802,0.0006970915,0.0003568689,0.002682927,0.0007990988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060271,"about_ca_system_score_gemma":0.00147422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002594679,"about_ca_topic_score_gemma":0.008854772,"domain_scores_codex":[0.99944,0.0002979417,0.00002345266,0.00008027362,0.00004944954,0.0001087891],"domain_scores_gemma":[0.9993985,0.00009080448,0.0001478912,0.00006963789,0.00004602134,0.0002472746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8373747,0.02053785,0.01468194,0.001812968,0.005586307,0.0002997853,0.0004234152,0.003392755,0.04657409,0.0003321439,0.00463504,0.06434907],"study_design_scores_gemma":[0.6899969,0.2710957,0.02716457,0.00006115231,0.002989607,0.0004857913,0.0001249487,0.0009166205,0.00267311,0.000186739,0.004246405,0.0000585729],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917428,0.003063568,0.0003851544,0.0003592976,0.0001037029,0.001133318,0.002001971,0.0001024729,0.001107753],"genre_scores_gemma":[0.9857452,0.003431562,0.001224688,0.0006996221,0.0001388643,0.001342782,0.004963835,0.0000531941,0.002400147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002594679,"threshold_uncertainty_score":0.008887947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0463892100952184,"score_gpt":0.401401696038203,"score_spread":0.3550124859429846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}