{"id":"W4382811312","doi":"10.1016/j.annonc.2023.04.055","title":"PD-28 Long-term efficacy and safety of larotrectinib in patients with tropomyosin receptor kinase (TRK) fusion gastrointestinal (GI) cancer: An updated analysis","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bayer Canada; Ono Pharmaceutical; Servier; Sociedad Española de Oncología Médica; European Society for Medical Oncology; Astellas Pharma; Seagen; Incyte; Bayer HealthCare; Sanofi; Natera; GlaxoSmithKline; Amgen; Pfizer; Mersana Therapeutics; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Trk receptor; Tropomyosin; Cancer; Receptor; Oncology; Internal medicine; Cancer research; Genetics; Neurotrophin; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002068288,0.0004815021,0.001965745,0.0006751267,0.0001574622,0.001215733,0.0006566563,0.0004072971,0.001478998],"category_scores_gemma":[0.002277878,0.0002820131,0.003397177,0.001174341,0.0002715114,0.001203929,0.0003981203,0.001409205,0.0003080974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001039821,"about_ca_system_score_gemma":0.0006632633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188412,"about_ca_topic_score_gemma":0.004012898,"domain_scores_codex":[0.9992981,0.0001335203,0.0001275445,0.0001302569,0.0002325951,0.00007789757],"domain_scores_gemma":[0.9983112,0.0006040297,0.0006731755,0.00007725607,0.0002457022,0.00008862478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.03251053,0.0006364218,0.225797,0.01195502,0.04536791,0.000549818,0.0001995444,0.004710404,0.005448706,0.0007471882,0.02047877,0.6515986],"study_design_scores_gemma":[0.01347685,0.009963955,0.7934585,0.00354074,0.08223348,0.003378997,0.0003062821,0.003856596,0.003060551,0.001662905,0.08482213,0.0002391245],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5203149,0.4590536,0.001238081,0.002053933,0.0003898578,0.0002495138,0.007981943,0.00009519562,0.008622932],"genre_scores_gemma":[0.8488841,0.1282939,0.001754777,0.003335374,0.0007783941,0.0002511787,0.01434337,0.0000472645,0.002311591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002068288,"threshold_uncertainty_score":0.01093823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0370812332683428,"score_gpt":0.3532725283364592,"score_spread":0.3161912950681164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}