{"id":"W4382888790","doi":"10.1248/cpb.c22-00926","title":"Concise Syntheses of Microsomal Metabolites of a Potent OXE (Oxoeicosanoid) Receptor Antagonist","year":2023,"lang":"en","type":"article","venue":"Chemical and Pharmaceutical Bulletin","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Division of Chemistry; National Heart, Lung, and Blood Institute; McGill University Health Centre; Canadian Institutes of Health Research; American Asthma Foundation; National Institutes of Health; National Science Foundation","keywords":"Chemistry; Microsome; Indole test; Antagonist; Stereochemistry; IC50; Chemotaxis; Metabolite; Chemical synthesis; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002053188,0.00018445,0.0003824774,0.00004419577,0.00004415654,0.000008683994,0.0001747989,0.000178662,0.0004037384],"category_scores_gemma":[0.0001891876,0.000153672,0.00014203,0.0001254622,0.0005280751,0.000001818224,0.0002673858,0.0001477608,0.00003176793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003419041,"about_ca_system_score_gemma":0.00003320136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006866043,"about_ca_topic_score_gemma":1.232802e-7,"domain_scores_codex":[0.9987391,0.00006868674,0.0003818088,0.0003564612,0.0001409525,0.0003129556],"domain_scores_gemma":[0.9992884,0.0001363213,0.00009157803,0.0001631613,0.0001152118,0.0002053124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005158329,0.0001619174,0.0006737706,0.0001192796,0.00008851867,0.000005583653,0.00001896224,8.393948e-7,0.9760209,0.0002118897,0.0188635,0.00331896],"study_design_scores_gemma":[0.0007821255,0.00008068844,0.0001006919,0.0000203997,0.00005552702,0.00001638134,0.00003592348,0.00004791264,0.7885279,0.0000287206,0.2101655,0.0001381631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936464,0.003175581,0.00001353424,0.001995243,0.0001257893,0.0001571343,0.0001571891,0.00002265456,0.0007064041],"genre_scores_gemma":[0.9958979,0.002254168,0.0003782104,0.0009416588,0.0001452142,0.00001773302,0.00009803511,0.00002058613,0.0002464807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.191302,"threshold_uncertainty_score":0.6266564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02534703111578274,"score_gpt":0.2947784261084285,"score_spread":0.2694313949926458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}