{"id":"W4382918749","doi":"10.1093/nar/gkad540","title":"ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Hospital for Sick Children; Japan Science and Technology Corporation; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Biology; Germline; Transposable element; Genetics; DNA methylation; Embryonic stem cell; Gene; Methylation; Embryogenesis; Computational biology; Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125241,0.0005858043,0.0002993508,0.0003464988,0.0002634912,0.0004044235,0.0003530444,0.0003356281,0.001606914],"category_scores_gemma":[0.0001328307,0.0002500644,0.0002073577,0.0001966657,0.0002540118,0.0002160881,0.0005681352,0.0003443686,0.0009900404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695429,"about_ca_system_score_gemma":0.000286166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005896501,"about_ca_topic_score_gemma":0.0009619133,"domain_scores_codex":[0.9998536,0.00001591583,0.00001397952,0.00004505304,0.00004451738,0.00002702874],"domain_scores_gemma":[0.9997992,0.00002079273,0.000070461,0.00002024234,0.00001300012,0.00007632562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009685358,0.000007437847,0.0003814042,0.00002653069,0.000003070506,0.0001716598,0.000008973185,0.00004012059,0.9980472,0.0001182607,0.00003908442,0.001059263],"study_design_scores_gemma":[0.00003145826,0.0001055721,0.01707265,0.00001281002,0.00001953083,0.001490105,0.00003433764,0.001210036,0.9718665,0.000123356,0.008021424,0.00001219108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822178,0.002971775,0.009898156,0.0001359931,0.00004457727,0.0000293689,0.00161669,0.0004770219,0.002608575],"genre_scores_gemma":[0.9887223,0.0006918549,0.004403332,0.00004667227,0.0000162519,0.00002870658,0.001962578,0.0001168335,0.004011421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606914,"threshold_uncertainty_score":0.005375683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05242152488937519,"score_gpt":0.3784496807096147,"score_spread":0.3260281558202395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}