{"id":"W4382930098","doi":"10.1101/2023.07.03.547316","title":"Mechanical Force Imprints Neutrophils to Orchestrate Pulmonary Homeostasis","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"School of Medicine, Shanghai Jiao Tong University; Shanghai Jiao Tong University; National Natural Science Foundation of China","keywords":"PIEZO1; Homeostasis; Mechanosensitive channels; Immune system; Lung; Biology; Cell biology; Immunology; Angiogenesis; Population; Inflammation; Medicine; Cancer research; Internal medicine; Ion channel; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005976359,0.0007883168,0.001193914,0.000580997,0.0001693849,0.00009423765,0.0004997201,0.001076188,0.0001749578],"category_scores_gemma":[0.0004331219,0.0008069872,0.0004053227,0.0009313314,0.000108482,0.00008426836,0.0009793418,0.001565813,0.001959351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003938843,"about_ca_system_score_gemma":0.0008663111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005885182,"about_ca_topic_score_gemma":0.000002276486,"domain_scores_codex":[0.9957978,0.0001866355,0.0007992285,0.001733713,0.0005271571,0.0009555064],"domain_scores_gemma":[0.9959608,0.0001266772,0.0003096281,0.002036016,0.0005747108,0.0009921099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004146492,0.0002321762,0.000895897,0.0007047268,0.000257865,0.000832934,0.000006366226,0.00007144881,0.994867,0.0005422689,0.001161521,0.00001311846],"study_design_scores_gemma":[0.002128881,0.001144948,0.4248481,0.001802134,0.0008245219,0.000001039062,0.00001738582,0.0008953072,0.5512746,0.0000641561,0.0145086,0.002490367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874047,0.000313723,0.001896454,0.002796178,0.003823925,0.001830965,0.0003328027,0.001564071,0.00003718706],"genre_scores_gemma":[0.990621,0.0006358101,0.004311405,0.00198113,0.001532538,0.0004688714,0.000002957325,0.0003100796,0.0001362143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4435924,"threshold_uncertainty_score":0.9994381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03624573875962613,"score_gpt":0.2619804970355997,"score_spread":0.2257347582759736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}