{"id":"W4382934436","doi":"10.1016/j.biopsych.2023.06.028","title":"A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes","year":2023,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Simon Fraser University; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Mental Health; Medical Research Council; National Institutes of Health, Pakistan; Canadian Institutes of Health Research; Directorate for Geosciences; National Institutes of Health; University of Bristol; National Medical Research Council; Hope for Depression Research Foundation; Medical Research Council Canada; Jacobs Foundation; Wellcome Trust","keywords":"Glucocorticoid; Mental health; Hippocampal formation; Psychology; Psychiatry; Gene; Neuroscience; Developmental psychology; Clinical psychology; Medicine; Biology; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009406961,0.0002013353,0.0003343088,0.00004529348,0.0003083777,0.00002286547,0.0002686135,0.00009065144,0.00004903764],"category_scores_gemma":[0.0002029491,0.0001037179,0.0003289612,0.0004266117,0.0001721882,0.00003267756,0.0001406755,0.0001970272,0.0001405605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004348371,"about_ca_system_score_gemma":0.0001616214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000151316,"about_ca_topic_score_gemma":0.00000800978,"domain_scores_codex":[0.9981689,0.0003997754,0.0002959121,0.0004181775,0.0002244279,0.0004927722],"domain_scores_gemma":[0.998876,0.0004724562,0.0001923847,0.0002970086,0.00001557802,0.0001465995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003348189,0.0003505252,0.971422,0.00000838508,0.00007696271,0.00001083116,0.000270085,0.005407295,0.007186153,0.002055562,0.007647844,0.002216225],"study_design_scores_gemma":[0.0004814683,0.001691213,0.9947214,0.00001697743,0.000003543867,0.000004896484,0.0001398713,0.00145152,0.000387197,0.000932007,0.00003457858,0.0001353513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958079,0.000128841,0.00002708092,0.002470311,0.0006602622,0.0004613824,0.0001706492,0.0001056821,0.0001679162],"genre_scores_gemma":[0.996655,0.0003856042,0.00004389857,0.002686718,0.0001297717,0.00000963119,0.00001178021,0.000009868234,0.00006774793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02329943,"threshold_uncertainty_score":0.4229492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06703957704885655,"score_gpt":0.3421720439418083,"score_spread":0.2751324668929517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}