{"id":"W4382934453","doi":"10.1101/2023.07.03.547533","title":"The substrate quality of CK2 target sites has a determinant role on their function and evolution","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval; PROTEO","funders":"Medical Research Council; Canadian Institutes of Health Research; Cancer Research UK; Wellcome Trust; Francis Crick Institute; European Molecular Biology Organization","keywords":"Kinase; Substrate (aquarium); Biology; Function (biology); Phosphorylation; Substrate specificity; Cell biology; Protein kinase domain; Selection (genetic algorithm); Biophysics; Computational biology; Enzyme; Biochemistry; Chemistry; Computer science; Gene; Artificial intelligence; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004634223,0.0003077657,0.0003095413,0.0003327765,0.0002373149,0.000852923,0.0002527765,0.0003528139,0.001789239],"category_scores_gemma":[0.0007518249,0.0001650349,0.0001580219,0.0003156568,0.0003145525,0.0005027748,0.000363025,0.0003369915,0.0004070344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000400914,"about_ca_system_score_gemma":0.0001119606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006349349,"about_ca_topic_score_gemma":0.000775571,"domain_scores_codex":[0.9998067,0.00004191459,0.00001368252,0.00005991101,0.00003924899,0.00003857477],"domain_scores_gemma":[0.9995449,0.0001687431,0.00013122,0.0000371329,0.00004340973,0.00007461682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005331314,0.00004709894,0.05413072,0.0001281216,0.00009774122,0.0002437876,0.00006132318,0.009820879,0.9200734,0.002129012,0.0001588307,0.01257589],"study_design_scores_gemma":[0.00005359821,0.0004443281,0.5204191,0.00004889476,0.0001876916,0.001901621,0.000348246,0.09604356,0.3700691,0.00421897,0.006169235,0.00009563293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949485,0.0004795989,0.00308992,0.00002948577,0.000004035579,0.000003701789,0.0001041274,0.00003067591,0.001309936],"genre_scores_gemma":[0.9987451,0.00009637196,0.0007313506,0.000009402112,0.000001405178,0.000002504227,0.0000891001,0.00001903524,0.0003056908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001789239,"threshold_uncertainty_score":0.005985618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02587725856157467,"score_gpt":0.2371554626755459,"score_spread":0.2112782041139712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}