{"id":"W4382934694","doi":"10.1111/cup.14494","title":"Telomerase reverse transcriptase immunohistochemical expression is sensitive but not specific for <i>TERT</i> gene amplification in acral melanoma","year":2023,"lang":"en","type":"article","venue":"Journal of Cutaneous Pathology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Jubilee Hospital","funders":"National Cancer Institute; Melanoma Research Alliance","keywords":"Immunohistochemistry; Pathology; Medicine; Fluorescence in situ hybridization; Telomerase reverse transcriptase; Melanoma; In situ hybridization; Telomerase; Gene expression; Molecular biology; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004599369,0.0002553525,0.0007422536,0.0005009593,0.00008935716,0.00001531894,0.0001728548,0.0002792674,0.00006039528],"category_scores_gemma":[0.0002256479,0.0002246206,0.0002992222,0.0003442735,0.0001702436,0.0001047819,0.00002611728,0.0005141923,0.00005007012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908395,"about_ca_system_score_gemma":0.0001506726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009274724,"about_ca_topic_score_gemma":0.000002119237,"domain_scores_codex":[0.9977036,0.0001337498,0.0009644799,0.0003743491,0.0003511359,0.0004726836],"domain_scores_gemma":[0.9984398,0.0002742275,0.0004002636,0.0003513898,0.0003165887,0.0002176769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00432242,0.0002038116,0.0005519431,0.00006667477,0.00002613276,0.01643018,0.002214113,0.000008879456,0.965116,0.00001169661,0.006895184,0.00415302],"study_design_scores_gemma":[0.003658304,0.001213284,0.00385499,0.0002420059,0.0001119058,0.05159859,0.001085166,0.0001365866,0.9266637,0.0001338019,0.01100181,0.0002998473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994854,0.0003579557,0.001203442,0.002233302,0.0006620335,0.0004458355,0.0001514704,0.00004193178,0.00005005599],"genre_scores_gemma":[0.9911672,0.001020143,0.005189012,0.001483675,0.0004197649,0.00001544076,0.00008658782,0.0000462977,0.0005718628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03845224,"threshold_uncertainty_score":0.9159763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02868100731608241,"score_gpt":0.2866254006614002,"score_spread":0.2579443933453178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}