{"id":"W4382934694","doi":"10.1111/cup.14494","title":"Telomerase reverse transcriptase immunohistochemical expression is sensitive but not specific for <i>TERT</i> gene amplification in acral melanoma","year":2023,"lang":"en","type":"article","venue":"Journal of Cutaneous Pathology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Jubilee Hospital","funders":"National Cancer Institute; Melanoma Research Alliance","keywords":"Immunohistochemistry; Pathology; Medicine; Fluorescence in situ hybridization; Telomerase reverse transcriptase; Melanoma; In situ hybridization; Telomerase; Gene expression; Molecular biology; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007390414,0.0002704588,0.0002036315,0.0007339599,0.0001171073,0.0003695292,0.0001587515,0.0002508659,0.001562971],"category_scores_gemma":[0.00140521,0.0001894918,0.0001602853,0.0002778733,0.0003825429,0.0002409269,0.0001803266,0.0002288691,0.0004734276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421804,"about_ca_system_score_gemma":0.00009271048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002976754,"about_ca_topic_score_gemma":0.0005548674,"domain_scores_codex":[0.9997185,0.00005533092,0.0000444616,0.00005555797,0.00008734554,0.00003879063],"domain_scores_gemma":[0.9988802,0.0004132712,0.0003930592,0.0000802139,0.0001707075,0.00006248197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005990925,0.00005831607,0.4313774,0.000284105,0.00007322529,0.003241132,0.0001592187,0.0002978274,0.5440968,0.0001031929,0.0002551134,0.01945465],"study_design_scores_gemma":[0.00005698888,0.0008594395,0.7336511,0.000088908,0.0002623953,0.04550952,0.0003153951,0.004682257,0.2103473,0.0002948892,0.003908885,0.00002298189],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933821,0.00171712,0.002618522,0.00003339378,0.00001547925,0.00002326646,0.00006915052,0.00007965842,0.002061398],"genre_scores_gemma":[0.9983197,0.0003333265,0.001064704,0.00001133155,0.00000801323,0.000008230498,0.00006100452,0.000004739612,0.0001889678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562971,"threshold_uncertainty_score":0.005228698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02868100731608241,"score_gpt":0.2866254006614002,"score_spread":0.2579443933453178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}