{"id":"W4382934820","doi":"10.1016/s2352-3026(23)00088-1","title":"Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Dasatinib; Internal medicine; Chemotherapy; Minimal residual disease; Clinical endpoint; Acute lymphocytic leukemia; Imatinib; Induction chemotherapy; Hematopoietic stem cell transplantation; Oncology; Chemotherapy regimen; Transplantation; Surgery; Pediatrics; Clinical trial; Leukemia; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003799214,0.0005321504,0.001840001,0.0003701057,0.0001284595,0.00003093198,0.0003968504,0.0003103274,0.0001727881],"category_scores_gemma":[0.0005249399,0.0003603645,0.0001614538,0.001278392,0.0004106631,0.00009635086,0.0001354833,0.0006031118,0.0002943327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001338219,"about_ca_system_score_gemma":0.000928292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001478571,"about_ca_topic_score_gemma":0.0002109768,"domain_scores_codex":[0.9966227,0.0003125086,0.0006581921,0.0007175381,0.0004044484,0.001284552],"domain_scores_gemma":[0.9971913,0.001181746,0.0003537106,0.0008366093,0.0002118345,0.0002248437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7091217,0.01257447,0.02811971,0.001503625,0.008537916,0.127162,0.03811001,0.0006828809,0.02464248,0.001947858,0.03195296,0.01564446],"study_design_scores_gemma":[0.9318027,0.01028022,0.007155645,0.001027217,0.002744335,0.0224421,0.002249762,0.00828899,0.01061567,0.0007906749,0.001443521,0.001159202],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982882,0.0004243204,0.00009826247,0.01298544,0.0003522969,0.002363849,0.00009114051,0.0003253932,0.0004772714],"genre_scores_gemma":[0.9934078,0.0006149993,0.0005080928,0.00378701,0.0008170437,0.0003355819,0.0002520715,0.0001117333,0.0001656996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.222681,"threshold_uncertainty_score":0.9998848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505073273147907,"score_gpt":0.3213202882339479,"score_spread":0.2862695555024689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}