{"id":"W4382934820","doi":"10.1016/s2352-3026(23)00088-1","title":"Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Dasatinib; Internal medicine; Chemotherapy; Minimal residual disease; Clinical endpoint; Acute lymphocytic leukemia; Imatinib; Induction chemotherapy; Hematopoietic stem cell transplantation; Oncology; Chemotherapy regimen; Transplantation; Surgery; Pediatrics; Clinical trial; Leukemia; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009720813,0.001221721,0.002464567,0.0002294181,0.0002342414,0.001012725,0.000753005,0.0009482458,0.003627772],"category_scores_gemma":[0.0008990853,0.0002966144,0.001438092,0.0004378907,0.0008042997,0.000936248,0.0004274988,0.003107061,0.0008566108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009215556,"about_ca_system_score_gemma":0.0008373453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007304188,"about_ca_topic_score_gemma":0.002604395,"domain_scores_codex":[0.9995582,0.0002201429,0.00002421081,0.00007629296,0.00003692578,0.00008422855],"domain_scores_gemma":[0.9995382,0.00008357404,0.00009960638,0.0000445415,0.00002237296,0.0002116791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7515615,0.006507566,0.004715171,0.002664199,0.005244608,0.0003238271,0.0003018092,0.004993618,0.0109225,0.0009776166,0.01037424,0.2014134],"study_design_scores_gemma":[0.9149569,0.06583187,0.009726974,0.00009091638,0.0009046677,0.0004771291,0.000092312,0.001036546,0.0009154572,0.0009675547,0.004957354,0.00004242646],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839236,0.008779677,0.0005247629,0.001225815,0.0002926746,0.0007133624,0.001303415,0.0001496477,0.003087166],"genre_scores_gemma":[0.9878008,0.004753162,0.001027715,0.001252883,0.0001276326,0.0008323151,0.001661586,0.00002792109,0.00251594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003627772,"threshold_uncertainty_score":0.0121361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505073273147907,"score_gpt":0.3213202882339479,"score_spread":0.2862695555024689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}