{"id":"W4382941063","doi":"10.3390/cancers15133451","title":"Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Genentech; National Cancer Institute; National Institutes of Health; Thomas Jefferson University; National Institute of General Medical Sciences; Sanofi; Eisai; University of Pennsylvania; Melanoma Research Alliance","keywords":"Fatty acid synthase; PI3K/AKT/mTOR pathway; Cancer research; Sterol regulatory element-binding protein; Cell growth; Downregulation and upregulation; Lipid metabolism; Fatty acid synthesis; Melanoma; Chemistry; Biology; Cell biology; Signal transduction; Fatty acid; Biochemistry; Cholesterol; Sterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427873,0.0002676264,0.0003344565,0.0002571834,0.0001799796,0.0002765275,0.0001673134,0.0002538387,0.0007116026],"category_scores_gemma":[0.0001172412,0.0001113426,0.000237457,0.0001819416,0.0002252541,0.0001767088,0.0001851841,0.0006302593,0.0002083204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003414898,"about_ca_system_score_gemma":0.0003797991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077118,"about_ca_topic_score_gemma":0.002738275,"domain_scores_codex":[0.9998468,0.00003042525,0.00001661206,0.00001987999,0.00004159102,0.00004464147],"domain_scores_gemma":[0.9999168,0.00001164596,0.00001787203,0.000009817062,0.000008349991,0.00003551033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005518395,0.0002510188,0.0003666277,0.0000590268,0.00001336493,0.00007071876,0.0000217477,0.000169366,0.9918956,0.0001586209,0.0002417312,0.006200364],"study_design_scores_gemma":[0.0001109915,0.003072647,0.004450814,0.00001204537,0.00003324808,0.0003856381,0.00007395575,0.00310089,0.9833812,0.00008623854,0.005284785,0.000007529879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943728,0.002197026,0.0009159101,0.0001909038,0.00006938133,0.00003805709,0.0001869837,0.000132305,0.001896634],"genre_scores_gemma":[0.9963105,0.0007253495,0.0008574602,0.00005462621,0.00001174456,0.00002920837,0.000167202,0.000009717029,0.001834164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077118,"threshold_uncertainty_score":0.002477705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009314410351195424,"score_gpt":0.2524530663686749,"score_spread":0.2431386560174795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}