{"id":"W4382982282","doi":"10.3390/cancers15133437","title":"Leveraging Gene Redundancy to Find New Histone Drivers in Cancer","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; Ontario Institute for Cancer Research; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Histone; Biology; Genetics; Histone H2A; Cancer epigenetics; Histone code; Chromatin; Epigenomics; Gene; Epigenetics; Computational biology; Histone methyltransferase; Gene expression; Nucleosome; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003716059,0.0002005723,0.0004451664,0.001531384,0.0002098493,0.0004521566,0.0002229348,0.0002632298,0.0004517469],"category_scores_gemma":[0.0009039345,0.0001894793,0.0002825395,0.001176532,0.000280524,0.0005053913,0.0003448413,0.0002516878,0.0001488882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002915351,"about_ca_system_score_gemma":0.0002641018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006419784,"about_ca_topic_score_gemma":0.001635007,"domain_scores_codex":[0.9997386,0.00004211881,0.00001725443,0.0001001318,0.00006947629,0.00003240495],"domain_scores_gemma":[0.9995597,0.0001652119,0.0001304768,0.00006137189,0.00003731126,0.0000459542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002795559,0.00005741993,0.1486011,0.0002082111,0.0001280107,0.0007245406,0.0002139179,0.00306607,0.8104641,0.001250751,0.0001711983,0.03483517],"study_design_scores_gemma":[0.0000172997,0.0003812229,0.6862338,0.00003609227,0.0002868142,0.004412412,0.0003447394,0.02361844,0.2713417,0.005031306,0.008231993,0.00006409934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873768,0.001764503,0.009675378,0.00007902148,0.000006236539,0.00002302289,0.0004883691,0.00008622358,0.0005004327],"genre_scores_gemma":[0.991488,0.0008180813,0.006919516,0.00004077767,0.000008371293,0.00001171305,0.0004718063,0.00001890102,0.0002229321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001531384,"threshold_uncertainty_score":0.002115309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561339363815892,"score_gpt":0.2790405287258654,"score_spread":0.2634271350877064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}