{"id":"W4382983620","doi":"10.3390/curroncol30070467","title":"Toxicity Profile of Chimeric Antigen Receptor T-Cell and Bispecific Antibody Therapies in Multiple Myeloma: Pathogenesis, Prevention and Management","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Chimeric antigen receptor; Bispecific antibody; Multiple myeloma; Adverse effect; Malignancy; Immunology; Immunotherapy; Clinical trial; Antigen; Cytokine release syndrome; Antibody; Intensive care medicine; Immune system; Monoclonal antibody; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008053482,0.0003776037,0.001905715,0.0007301768,0.00005375269,0.00001447623,0.0001627255,0.0003038121,0.0003577048],"category_scores_gemma":[0.00004044958,0.000312268,0.000222339,0.0007226757,0.0002433286,0.00003800445,0.0002724394,0.0004366,0.00003922854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000223998,"about_ca_system_score_gemma":0.0002345824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001002927,"about_ca_topic_score_gemma":0.00002414534,"domain_scores_codex":[0.9972635,0.0005641968,0.0007932304,0.0006812661,0.0002937409,0.0004041005],"domain_scores_gemma":[0.998779,0.0002706959,0.0003780958,0.0003836844,0.0000675349,0.0001209784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001180566,0.0008368334,0.002660912,0.03873052,0.0002092964,0.00002879196,0.0001778436,2.774871e-8,0.001992003,0.00001362907,0.0003325069,0.9548996],"study_design_scores_gemma":[0.002176629,0.0007963744,0.006149207,0.006912817,0.0002967782,0.00002549575,0.0001565472,0.00001394257,0.00009297515,0.00001399258,0.9831091,0.0002561526],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03686383,0.9580137,0.00001393412,0.00002694491,0.0004921674,0.004088814,0.00007596856,0.00004289295,0.0003818015],"genre_scores_gemma":[0.0001819022,0.9968299,0.0003286313,0.000003029621,0.0001578243,0.0004142977,0.0005242052,0.0000742933,0.001485868],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9827766,"threshold_uncertainty_score":0.9999329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1856902768169878,"score_gpt":0.4573332689036392,"score_spread":0.2716429920866514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}