{"id":"W4382983620","doi":"10.3390/curroncol30070467","title":"Toxicity Profile of Chimeric Antigen Receptor T-Cell and Bispecific Antibody Therapies in Multiple Myeloma: Pathogenesis, Prevention and Management","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Chimeric antigen receptor; Bispecific antibody; Multiple myeloma; Adverse effect; Malignancy; Immunology; Immunotherapy; Clinical trial; Antigen; Cytokine release syndrome; Antibody; Intensive care medicine; Immune system; Monoclonal antibody; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007007332,0.0005229715,0.001119619,0.001196397,0.000177645,0.0006758461,0.0006121428,0.0007271785,0.001965728],"category_scores_gemma":[0.0007689166,0.0001689373,0.000698467,0.001156904,0.0002055551,0.0005941355,0.0003882652,0.0009479097,0.0006010729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005716613,"about_ca_system_score_gemma":0.0008665518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008972799,"about_ca_topic_score_gemma":0.001693157,"domain_scores_codex":[0.9997591,0.00005911389,0.00004237277,0.00003171299,0.00008890709,0.00001872289],"domain_scores_gemma":[0.9996861,0.0001512417,0.00005888694,0.000006511296,0.00008292683,0.00001430842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000143709,0.00006432143,0.0002880516,0.02274951,0.0002055767,0.0001896014,0.00004906377,0.0005503029,0.002000373,0.001501943,0.01625985,0.9559978],"study_design_scores_gemma":[0.0000769191,0.0005163398,0.002443222,0.009883459,0.0007471829,0.003281029,0.0000869658,0.0002760757,0.001910552,0.001755013,0.9789904,0.00003280664],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002677845,0.9988109,0.00007689858,0.0001880258,0.00007166102,0.000004688853,0.00001940994,0.000003836688,0.0005569331],"genre_scores_gemma":[0.001522888,0.9976914,0.0001244138,0.0002008369,0.00008855118,0.000007649822,0.00003811362,0.000001241589,0.0003249752],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001965728,"threshold_uncertainty_score":0.006576002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1856902768169878,"score_gpt":0.4573332689036392,"score_spread":0.2716429920866514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}