{"id":"W4382986988","doi":"10.1016/j.hoc.2023.05.021","title":"Emerging Biomarkers of Response to Systemic Therapies in Metastatic Clear Cell Renal Cell Carcinoma","year":2023,"lang":"en","type":"review","venue":"Hematology/Oncology Clinics of North America","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Renal cell carcinoma; Systemic therapy; Immunotherapy; Oncology; Biomarker; Clear cell renal cell carcinoma; Internal medicine; Intensive care medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001042714,0.0007637168,0.002545972,0.00150826,0.0001422534,0.001294886,0.0006608426,0.0007137008,0.001644069],"category_scores_gemma":[0.001978058,0.000239298,0.001102812,0.001766537,0.0003412392,0.0008479656,0.0004607526,0.001529815,0.0005829881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006302194,"about_ca_system_score_gemma":0.001091592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001547949,"about_ca_topic_score_gemma":0.003142329,"domain_scores_codex":[0.9997371,0.00006474039,0.00005218593,0.00004313228,0.0000809617,0.00002194401],"domain_scores_gemma":[0.9992427,0.0004297131,0.0001579035,0.00001176957,0.0001339214,0.0000240047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002059758,0.00005967055,0.001090148,0.01737057,0.0004651548,0.00008927438,0.00002948585,0.0003500718,0.0006014183,0.001026488,0.01424785,0.9644638],"study_design_scores_gemma":[0.0003722181,0.000926597,0.01482192,0.03700185,0.005627188,0.00191178,0.0002141721,0.001057143,0.001824905,0.003981152,0.932147,0.0001141252],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001193703,0.999275,0.00006891009,0.0001706691,0.00007974271,0.000003443711,0.00002240281,0.000003738352,0.0002566679],"genre_scores_gemma":[0.00188238,0.997193,0.0002352525,0.0002916948,0.0001525316,0.00001119095,0.00004949313,9.885657e-7,0.0001834416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002545972,"threshold_uncertainty_score":0.005514443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06889863237091014,"score_gpt":0.3803642281189145,"score_spread":0.3114655957480044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}