{"id":"W4383058381","doi":"10.1097/hep.0000000000000529","title":"Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?","year":2023,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto; University Health Network","funders":"Dr. Falk Pharma; Grifols; AOP Orphan; Eisai; Ipsen; Falk Foundation; National Institute for Health and Care Research; Swedish Orphan Biovitrum; Bristol-Myers Squibb; Eli Lilly and Company; CSL Behring; GlaxoSmithKline; Gilead Sciences; Kowa Company","keywords":"Ursodeoxycholic acid; Medicine; Gastroenterology; Internal medicine; Liver transplantation; Primary biliary cirrhosis; Alkaline phosphatase; Complication; Bilirubin; Hepatology; Cohort; Incidence (geometry); Retrospective cohort study; Surgery; Transplantation; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004372149,0.0002126028,0.0004198296,0.0003376484,0.0001432134,0.00008092891,0.000188474,0.0001266409,0.0002070493],"category_scores_gemma":[0.0003268354,0.000201132,0.00005565926,0.0008061748,0.0001252822,0.0005202094,0.0002447672,0.0002248506,0.0002321189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000233701,"about_ca_system_score_gemma":0.0001657159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004672211,"about_ca_topic_score_gemma":0.0006749711,"domain_scores_codex":[0.9982068,0.0003074942,0.000303054,0.000433942,0.0002596909,0.0004890193],"domain_scores_gemma":[0.9981462,0.0005496613,0.00007351907,0.0006845603,0.0001581731,0.0003878969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1147334,0.0057355,0.7606784,0.0004282185,0.003019237,0.003849826,0.02150547,0.00034208,0.01227898,0.002502664,0.04602346,0.02890278],"study_design_scores_gemma":[0.007005433,0.0008319045,0.9865991,0.0002481675,0.0001565382,0.00004581983,0.00326198,0.0005153827,0.0003257885,0.0001093213,0.0006445824,0.0002559191],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817602,0.001500894,0.0001396838,0.01483131,0.0003396176,0.0007196798,0.0005641776,0.0001013013,0.0000431644],"genre_scores_gemma":[0.9880531,0.0007439502,0.0001160532,0.00882064,0.00002837148,0.0002031782,0.001799557,0.00003455267,0.0002006307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2259207,"threshold_uncertainty_score":0.8201925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06010202142329193,"score_gpt":0.3157027525270813,"score_spread":0.2556007311037894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}