{"id":"W4383058381","doi":"10.1097/hep.0000000000000529","title":"Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?","year":2023,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto; University Health Network","funders":"Dr. Falk Pharma; Grifols; AOP Orphan; Eisai; Ipsen; Falk Foundation; National Institute for Health and Care Research; Swedish Orphan Biovitrum; Bristol-Myers Squibb; Eli Lilly and Company; CSL Behring; GlaxoSmithKline; Gilead Sciences; Kowa Company","keywords":"Ursodeoxycholic acid; Medicine; Gastroenterology; Internal medicine; Liver transplantation; Primary biliary cirrhosis; Alkaline phosphatase; Complication; Bilirubin; Hepatology; Cohort; Incidence (geometry); Retrospective cohort study; Surgery; Transplantation; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002963568,0.0002465923,0.0005017531,0.0006104419,0.0001367163,0.0006807168,0.000235176,0.0003805333,0.0008215805],"category_scores_gemma":[0.005613011,0.0001447806,0.000632045,0.0007106317,0.0005488487,0.0004776328,0.0004937953,0.0003716116,0.0001367387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002378198,"about_ca_system_score_gemma":0.0002115521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003896583,"about_ca_topic_score_gemma":0.0005231386,"domain_scores_codex":[0.9986656,0.0006945519,0.0001590419,0.000203989,0.0001398136,0.0001370816],"domain_scores_gemma":[0.9946889,0.002280023,0.002053341,0.0003723985,0.0002068062,0.0003985697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001924577,0.00001789958,0.9949078,0.0000197556,0.0001390684,0.00005116083,0.0000285703,0.00006112747,0.0002884781,0.0000146226,0.00001915104,0.002527832],"study_design_scores_gemma":[0.00003569649,0.0009744333,0.9971768,0.00001074062,0.0002664021,0.0005428128,0.0001369217,0.0004486409,0.0001836237,0.0000857151,0.0001333619,0.000004841058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988468,0.0008047043,0.0001306131,0.00003089606,0.000003847774,0.000003431019,0.00005454562,0.00000153943,0.0001236702],"genre_scores_gemma":[0.9997998,0.00007516586,0.00003181494,0.000009673921,0.000007755606,0.000001676407,0.00005364495,7.923991e-7,0.00001962474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002963568,"threshold_uncertainty_score":0.01567304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06010202142329193,"score_gpt":0.3157027525270813,"score_spread":0.2556007311037894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}