{"id":"W4383058646","doi":"10.1002/cam4.6272","title":"Association of the <scp> <i>CHEK2</i> </scp> c. <scp>1100delC</scp> variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival","year":2023,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council Tasmania; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Health and Medical Research Council; Oulun Yliopisto; National Center for Chronic Disease Prevention and Health Promotion; Deutsche Krebshilfe; Centers for Disease Control and Prevention; Institut National Du Cancer; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Syöpäsäätiö; Vetenskapsrådet; Stockholms Läns Landsting; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; European Regional Development Fund; King's College London; Academy of Finland; University of Crete; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Agence Nationale de la Recherche; Huntsman Cancer Foundation; Robert Bosch Stiftung; FP7 Ideas: European Research Council; Agency for Science, Technology and Research; National Institute of Environmental Health Sciences; U.S. Army; University of Westminster; National Breast Cancer Foundation; European Commission; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of Utah; Breast Cancer Campaign; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; Deutsches Krebsforschungszentrum; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; National Institute for Health and Care Research; Norges Forskningsråd; Division of Cancer Prevention, National Cancer Institute; Karolinska Institutet; Harvard T.H. Chan School of Public Health; Freistaat Sachsen; Huntsman Cancer Institute; University of California; Intermountain Healthcare; Cancer Council Victoria; California Department of Public Health; Lon V. Smith Foundation; Genome Canada; Itä-Suomen Yliopisto; Brigham and Women's Hospital; Ministerio de Sanidad, Servicios Sociales e Igualdad; Government of Canada; University of Cambridge; Breast Cancer Research Foundation; Cancer Council NSW; Susan G. Komen for the Cure; Eberhard Karls Universität Tübingen; Wellcome Trust; Fondation du cancer du sein du Québec; Memorial Sloan-Kettering Cancer Center; Cancer Research UK; Stavros Niarchos Foundation; University of Southern California; Kreftforeningen; University of California, San Francisco; U.S. Department of Health and Human Services","keywords":"Breast cancer; Medicine; Oncology; Internal medicine; Radiation therapy; Systemic therapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006252174,0.0001956469,0.000345483,0.0002284028,0.0001847825,0.0004075374,0.0002978091,0.000304093,0.002678045],"category_scores_gemma":[0.001713861,0.0001331659,0.0008131941,0.0003667033,0.0001829045,0.0001603057,0.0002102623,0.0004942062,0.0001266352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004428652,"about_ca_system_score_gemma":0.0004454848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006258021,"about_ca_topic_score_gemma":0.005567802,"domain_scores_codex":[0.9997208,0.00007598977,0.00002195688,0.00009805917,0.00003864222,0.00004466203],"domain_scores_gemma":[0.9985257,0.0005970733,0.0005377199,0.000131623,0.00006117424,0.0001468401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001287885,0.00005570704,0.9928583,0.00002015148,0.0003801619,0.00009146219,0.00002334329,0.0009419494,0.00110273,0.00004927817,0.0001516273,0.003037498],"study_design_scores_gemma":[0.00003032383,0.0002819147,0.9943696,0.000006013858,0.0003472887,0.0003830485,0.00002245153,0.003835559,0.0003956683,0.00009120252,0.0002300273,0.000007038071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989353,0.0002308054,0.0002786796,0.00004745007,0.000004386922,0.000004125875,0.0002413032,0.000007442165,0.0002504284],"genre_scores_gemma":[0.9994462,0.00004147397,0.00008585022,0.000009563243,0.000003937103,0.000005213979,0.0002408639,0.000003022553,0.0001639392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006258021,"threshold_uncertainty_score":0.01244318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008281098908568749,"score_gpt":0.2476043867488104,"score_spread":0.2393232878402416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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