{"id":"W4383058646","doi":"10.1002/cam4.6272","title":"Association of the <scp> <i>CHEK2</i> </scp> c. <scp>1100delC</scp> variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival","year":2023,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council Tasmania; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Health and Medical Research Council; Oulun Yliopisto; National Center for Chronic Disease Prevention and Health Promotion; Deutsche Krebshilfe; Centers for Disease Control and Prevention; Institut National Du Cancer; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Syöpäsäätiö; Vetenskapsrådet; Stockholms Läns Landsting; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; European Regional Development Fund; King's College London; Academy of Finland; University of Crete; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Agence Nationale de la Recherche; Huntsman Cancer Foundation; Robert Bosch Stiftung; FP7 Ideas: European Research Council; Agency for Science, Technology and Research; National Institute of Environmental Health Sciences; U.S. Army; University of Westminster; National Breast Cancer Foundation; European Commission; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of Utah; Breast Cancer Campaign; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; Deutsches Krebsforschungszentrum; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; National Institute for Health and Care Research; Norges Forskningsråd; Division of Cancer Prevention, National Cancer Institute; Karolinska Institutet; Harvard T.H. Chan School of Public Health; Freistaat Sachsen; Huntsman Cancer Institute; University of California; Intermountain Healthcare; Cancer Council Victoria; California Department of Public Health; Lon V. Smith Foundation; Genome Canada; Itä-Suomen Yliopisto; Brigham and Women's Hospital; Ministerio de Sanidad, Servicios Sociales e Igualdad; Government of Canada; University of Cambridge; Breast Cancer Research Foundation; Cancer Council NSW; Susan G. Komen for the Cure; Eberhard Karls Universität Tübingen; Wellcome Trust; Fondation du cancer du sein du Québec; Memorial Sloan-Kettering Cancer Center; Cancer Research UK; Stavros Niarchos Foundation; University of Southern California; Kreftforeningen; University of California, San Francisco; U.S. Department of Health and Human Services","keywords":"Breast cancer; Medicine; Oncology; Internal medicine; Radiation therapy; Systemic therapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003795701,0.0003478052,0.0005078597,0.00007865647,0.0001868665,0.0000284473,0.0001938873,0.0002124564,0.00002826521],"category_scores_gemma":[0.0000414563,0.0002271355,0.0000682893,0.0004326998,0.0003225897,0.0000140735,0.00005802631,0.000163552,7.983861e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007060362,"about_ca_system_score_gemma":0.0004764747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0028261,"about_ca_topic_score_gemma":0.001896588,"domain_scores_codex":[0.9980237,0.0001855356,0.0003770254,0.0005896214,0.0003682078,0.0004559215],"domain_scores_gemma":[0.9985017,0.0001875369,0.0004705633,0.0004088863,0.0002812419,0.000150045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009200575,0.00005394141,0.8002754,0.0001883579,0.001675961,0.000009904213,0.003056673,0.001310279,0.1389434,0.00002928641,0.0385764,0.01578835],"study_design_scores_gemma":[0.01176334,0.00065002,0.8824327,0.0009410945,0.001057787,0.0003837887,0.002477265,0.0007559812,0.01219155,0.00004400235,0.08708861,0.0002138925],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606681,0.03302091,0.0001408788,0.002116464,0.00113823,0.0006243301,0.002096777,0.0000355199,0.0001587459],"genre_scores_gemma":[0.9045871,0.08992238,0.00002423373,0.0002825057,0.001472081,0.0003917378,0.00006957206,0.00006558689,0.003184796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1267518,"threshold_uncertainty_score":0.9262316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008281098908568749,"score_gpt":0.2476043867488104,"score_spread":0.2393232878402416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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