{"id":"W4383058836","doi":"10.1002/bies.202300088","title":"Defining bone fide effectors of RAS GTPases","year":2023,"lang":"en","type":"review","venue":"BioEssays","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Effector; GTPase; Cell biology; Biology; Function (biology); Small GTPase; GTPase-activating protein; Ras superfamily; GTP-binding protein regulators; Signal transduction; Computational biology; G protein; Biochemistry; GTP'","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003916022,0.000805007,0.0008673423,0.001901545,0.0002526447,0.001044315,0.0006562246,0.0008365446,0.002299567],"category_scores_gemma":[0.0003843498,0.0002949659,0.0003233461,0.00167461,0.0004847964,0.001600521,0.0008004298,0.001800696,0.002774106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005707001,"about_ca_system_score_gemma":0.0007282041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005625337,"about_ca_topic_score_gemma":0.0007454867,"domain_scores_codex":[0.999872,0.00001635786,0.00001308174,0.00002747375,0.00005228409,0.00001868601],"domain_scores_gemma":[0.9998871,0.0000377238,0.00001745312,0.000004681022,0.00003603715,0.0000170423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001089613,0.00006598289,0.000159741,0.01504424,0.00004620215,0.0003107179,0.0001263627,0.0005523694,0.01190074,0.01357543,0.02761355,0.9304956],"study_design_scores_gemma":[0.000006366223,0.00005659269,0.0003411515,0.00100404,0.00002440623,0.0005621568,0.00003947523,0.00006383438,0.001097552,0.001866319,0.994928,0.00001017382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002068781,0.9977503,0.0001961482,0.0001880078,0.0001986939,0.000003404645,0.00001499546,0.000009524299,0.001431901],"genre_scores_gemma":[0.000944785,0.9976041,0.0001985276,0.000144863,0.0001433443,0.000005532233,0.00002955967,0.000001895039,0.0009274194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002299567,"threshold_uncertainty_score":0.007692873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03532577730742816,"score_gpt":0.3266244621592013,"score_spread":0.2912986848517732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}