{"id":"W4383067588","doi":"10.1038/s41419-023-05923-9","title":"E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR","year":2023,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Second Military Medical University; Chinese Academy of Medical Sciences; Government of Jiangsu Province; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Directorate for Biological Sciences; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Protein kinase R; Viral replication; Biology; Ubiquitin ligase; Virus; Ubiquitin; Virology; RNA silencing; Cell biology; RNA; RNA virus; Kinase; Protein kinase A; RNA interference; Mitogen-activated protein kinase kinase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147395,0.0001367351,0.0001589258,0.0001715524,0.0001474948,0.00002055538,0.00006991543,0.0001170591,0.00006189259],"category_scores_gemma":[0.000326471,0.0001266694,0.00004716855,0.0001244361,0.00007823157,0.0001289052,0.00006394363,0.00009303359,0.0001068449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001505552,"about_ca_system_score_gemma":0.00006754634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008429312,"about_ca_topic_score_gemma":0.000004618224,"domain_scores_codex":[0.9990826,0.0001399362,0.0002648271,0.0002845119,0.00003604,0.0001921176],"domain_scores_gemma":[0.9993336,0.0001050821,0.0001319918,0.0002851264,0.00007804874,0.0000661748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007645905,0.00006825347,0.0004814488,0.00009665581,0.00001938989,0.000004119465,0.00034975,4.130612e-7,0.9797392,0.0002782978,0.0002615267,0.01793631],"study_design_scores_gemma":[0.0008627272,0.0001972992,0.05357169,0.00003815475,0.00005337119,0.000005041193,0.00006627884,0.0001773244,0.9432395,0.000525552,0.001130778,0.0001323341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970227,0.001646215,0.00007852573,0.0003238478,0.0001067907,0.0003292277,0.00004578306,0.00009420441,0.0003527237],"genre_scores_gemma":[0.997959,0.0003459396,0.00001092793,0.00008999899,0.00002530859,0.00003717022,0.0003105742,0.0000133611,0.001207727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05309024,"threshold_uncertainty_score":0.5165427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174161385528531,"score_gpt":0.2576466037983409,"score_spread":0.2402304652454878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}