{"id":"W4383103895","doi":"10.1016/j.tem.2023.06.004","title":"Blood-based bioenergetics: a liquid biopsy of mitochondrial dysfunction in disease","year":2023,"lang":"en","type":"review","venue":"Trends in Endocrinology and Metabolism","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Queen's University; Canada Research Chairs; Canada Foundation for Innovation; Banting Research Foundation","keywords":"Mitochondrion; Bioenergetics; Platelet; Disease; Biomarker; Pathophysiology; Oxidative phosphorylation; Biology; Medicine; Mitochondrial DNA; Pathology; Immunology; Bioinformatics; Cell biology; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001342427,0.0004543941,0.001345239,0.00129072,0.00003400305,0.000006959941,0.0002327027,0.0006150808,0.00008444004],"category_scores_gemma":[0.0002079726,0.0004119122,0.0003546856,0.0006344158,0.0002662229,0.000004141525,0.0001514577,0.0003878027,0.00001346059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001045726,"about_ca_system_score_gemma":0.0001875312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005759511,"about_ca_topic_score_gemma":0.0001762235,"domain_scores_codex":[0.9972578,0.0004944487,0.0008276675,0.0008172387,0.0001065014,0.0004964001],"domain_scores_gemma":[0.9989425,0.00006701111,0.0002891191,0.0005361135,0.00003791507,0.0001273721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004234719,0.001572898,0.0004684193,0.009531195,0.001047848,0.001202601,0.000145843,0.0001509709,0.01392381,0.007029123,0.002113112,0.9585795],"study_design_scores_gemma":[0.002328122,0.0002413142,0.0001798731,0.0005460527,0.0006968183,0.00007382502,0.000008500691,0.000004367168,0.0004039854,0.00004941816,0.9950586,0.000409155],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003716359,0.9925738,0.0000646474,0.00004904798,0.002852171,0.0003010286,0.0001952578,0.00002977397,0.0002179188],"genre_scores_gemma":[0.0002029086,0.9959416,0.0003878114,0.00005488041,0.0006694511,0.0002703646,0.001037386,0.0000613189,0.001374325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9929454,"threshold_uncertainty_score":0.9998333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03614888742866908,"score_gpt":0.3166216019141886,"score_spread":0.2804727144855196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}