{"id":"W4383186097","doi":"10.1128/mbio.00789-23","title":"Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Mitacs; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Canon Foundation in Europe; Government of Canada; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Degranulation; Cell biology; CD16; Receptor; Cytotoxicity; Immunological synapse; Biology; Chemistry; T cell; Immunology; Immune system; Biochemistry; T-cell receptor; In vitro; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273903,0.0002586088,0.0003693797,0.0001139307,0.0001491515,0.0004191156,0.0002740214,0.0002797897,0.001659936],"category_scores_gemma":[0.0001732821,0.0001029985,0.0001620634,0.0001166899,0.0001835135,0.0001974076,0.0001717118,0.0005404016,0.0002894472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699281,"about_ca_system_score_gemma":0.0001879323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006785118,"about_ca_topic_score_gemma":0.0006681361,"domain_scores_codex":[0.9998122,0.00004259169,0.00002169365,0.00002491289,0.00003640448,0.00006234803],"domain_scores_gemma":[0.9999189,0.00002701768,0.00001420085,0.00001356709,0.000009141579,0.00001707944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009145802,0.0002577961,0.0003063451,0.00006391497,0.00001214154,0.00009495425,0.00002192017,0.0002256474,0.9947744,0.0001488578,0.00009248055,0.003087074],"study_design_scores_gemma":[0.00006785399,0.00138717,0.003742136,0.000007235688,0.00002015046,0.000162109,0.00002340623,0.001134096,0.9920419,0.00003665283,0.001371301,0.000005941191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978515,0.001040852,0.0001202957,0.00003202161,0.00003312608,0.00001317583,0.0001303751,0.00001305587,0.0007657306],"genre_scores_gemma":[0.9982964,0.0004515521,0.0002485625,0.00002239684,0.000009631742,0.00002085854,0.0001894529,0.000005322995,0.0007556971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001659936,"threshold_uncertainty_score":0.005553007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229809266643514,"score_gpt":0.2581910054455226,"score_spread":0.2458929127790875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}