{"id":"W4383186097","doi":"10.1128/mbio.00789-23","title":"Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Mitacs; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Canon Foundation in Europe; Government of Canada; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Degranulation; Cell biology; CD16; Receptor; Cytotoxicity; Immunological synapse; Biology; Chemistry; T cell; Immunology; Immune system; Biochemistry; T-cell receptor; In vitro; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002641421,0.0001886195,0.0003309684,0.0003491397,0.00007926401,0.000006515372,0.0001418536,0.0003017574,0.002589384],"category_scores_gemma":[0.0001224332,0.0001620548,0.0002214608,0.00039569,0.0001033886,0.00009294157,0.00004935761,0.0002631601,0.003730267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008249255,"about_ca_system_score_gemma":0.0000558176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002524478,"about_ca_topic_score_gemma":0.000003942525,"domain_scores_codex":[0.9987254,0.0001830915,0.000480257,0.0002504993,0.000079989,0.0002807195],"domain_scores_gemma":[0.9989967,0.0001875135,0.0003285063,0.0003252228,0.0001384974,0.00002355531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005178927,0.0003423041,0.006215138,0.00003088509,0.0001393251,0.000002728637,0.0002201046,0.0001639313,0.9827175,0.00002454755,0.009520637,0.0001049894],"study_design_scores_gemma":[0.001578028,0.0006860499,0.132237,0.00004032262,0.00002885842,0.000003980344,0.0001254425,0.0002220099,0.8636431,0.000009972178,0.001279155,0.0001460967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961369,0.0001378344,0.0001280657,0.00004391098,0.00108013,0.0002523025,0.00009557039,0.0001289662,0.001996308],"genre_scores_gemma":[0.9887747,0.00008634113,0.000003471745,0.00002495775,0.00002289053,0.000006414919,0.00355282,0.00002033203,0.007508054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1260219,"threshold_uncertainty_score":0.9983224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229809266643514,"score_gpt":0.2581910054455226,"score_spread":0.2458929127790875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}