{"id":"W4383186313","doi":"10.1093/nar/gkad563","title":"The fission yeast methyl phosphate capping enzyme Bmc1 guides 2′-O-methylation of the U6 snRNA","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Northern British Columbia; University of British Columbia; York University","funders":"Natural Sciences and Engineering Research Council of Canada; Alliance de recherche numérique du Canada","keywords":"Biology; Small nuclear RNA; snRNP; RNA splicing; Small nucleolar RNA; Methylation; RNA; Telomerase; Pseudouridine; Genetics; Spliceosome; Schizosaccharomyces; Non-coding RNA; Cell biology; Schizosaccharomyces pombe; Molecular biology; Biochemistry; Transfer RNA; Yeast; DNA; Saccharomyces cerevisiae; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009800393,0.0004015785,0.0002046948,0.0001663169,0.0002855686,0.0003121991,0.0002770897,0.0003023288,0.000826677],"category_scores_gemma":[0.0002103718,0.0001707629,0.0002352318,0.00009189788,0.0001819336,0.0001830832,0.0003401599,0.0003583379,0.0006494289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004994448,"about_ca_system_score_gemma":0.0002462206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145435,"about_ca_topic_score_gemma":0.002026783,"domain_scores_codex":[0.9999094,0.000005906154,0.00000542766,0.000027574,0.00003543808,0.00001619867],"domain_scores_gemma":[0.9999064,0.00001500303,0.00002960092,0.00001189414,0.00001049692,0.00002662096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009373733,0.000008455868,0.0006203424,0.00003243064,0.000003080424,0.00009874618,0.00001513479,0.000118164,0.9952524,0.0002259215,0.00009985797,0.003431709],"study_design_scores_gemma":[0.00000578032,0.00004806868,0.003781702,0.000003320397,0.00000654652,0.0002845365,0.00001560911,0.001186247,0.9906342,0.00005569952,0.003974471,0.000003807319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874982,0.001865656,0.007865794,0.0001198198,0.00003165901,0.00001669135,0.0007075664,0.0004236111,0.001470939],"genre_scores_gemma":[0.9894869,0.0004976963,0.006020346,0.00003622139,0.000007020497,0.00001184542,0.001366606,0.00006250823,0.002510661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145435,"threshold_uncertainty_score":0.003623724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05842561082505343,"score_gpt":0.364429561878582,"score_spread":0.3060039510535286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}